The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Neuroleptics and the Natural Course of Schizophrenia
Abstract
To determine if neuroleptic treatment changes the natural course of schizophrenia, 22 studies were reviewed in which relatively similar patients were or were not given neuroleptics at specific times during the course of their illness. Nineteen of the studies were from first- or predominantly first-break populations. While there was little consensus among the authors of the studies reviewed, a reanalysis of the data indicates that early intervention with neuroleptics in first-break schizophrenic patients increases the likelihood of an improved long-term course. This finding is similar to that of earlier investigators who indicated there was a decrease in patients with the more severe forms of the illness following the introduction of convulsive therapies. Furthermore, there is evidence that stable schizophrenic patients whose neuroleptics are discontinued and have relapses may have a difficult time returning to their previous level of function. The findings describe in this paper have implications for both the treatment of schizophrenia and for understanding the pathophysiological processes that determine the course of the disorder.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The notion that schizophrenia pathology worsen over time is supported by studies that suggest that long-term morbidity increases in the absence of any treatment 45,46 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [45]
Citations
Cites
Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,907
Statistical Methods for Survival Data Analysis.
Lachenbruch, P. A., & Lee, E. T. (1993) · Journal of the American Statistical Association · doi:10.2307/2290742 · Cited by 2,851
International Classification of Diseases, 10th Revision
Tassé, M. J., & Bush, K. (2018) · Sage eBooks · doi:10.4135/9781483392271.n276 · Cited by 1,921
Drug and Family Therapy in the Aftercare of Acute Schizophrenics
Goldstein, M. J. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770340019001 · Cited by 521
II. A Randomised Controlled Trial of Prophylactic Neuroleptic Treatment
Crow, T. J., Macmillan, J. F., Johnson, A. L., & Johnstone, E. C. (1986) · The British Journal of Psychiatry · doi:10.1192/bjp.148.2.120 · Cited by 491
Wyatt, R. J., Alexander, R., Egan, M. F., & Kirch, D. G. (1988) · Schizophrenia Research · doi:10.1016/0920-9964(88)90034-5 · Cited by 478
Self-citationNeuropathology of Schizophrenia
Stevens, J. R. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290100011003 · Cited by 474
Longitudinal Studies of Schizophrenic Patients
Huber, G., Gross, G., Schüttler, R., Linz, M. H., & Clemens, S. L. (1980) · Schizophrenia Bulletin · doi:10.1093/schbul/6.4.592 · Cited by 439
Cited by
Sorted by citations
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
The Prodromal Phase of First-episode Psychosis: Past and Current Conceptualizations
Yung, A. R., & McGorry, P. D. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.353 · Cited by 1,168
Neurocognition in first-episode schizophrenia: a meta-analytic review.
Mesholam-Gately, R. I., Giuliano, A. J., Goff, K. P., Faraone, S. V., & Seidman, L. J. (2009) · Neuropsychology · doi:10.1037/a0014708 · Cited by 1,130
EPPIC: An Evolving System of Early Detection and Optimal Management
McGorry, P. D., Edwards, J., Mihalopoulos, C., Harrigan, S., & Jackson, H. J. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.2.305 · Cited by 936
Duration of psychosis and outcome in first-episode schizophrenia
Loebel, A. D., Lieberman, J. A., Alvir, J. M., Mayerhoff, D. I., Geisler, S. H., & Szymanski, S. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1183 · Cited by 880
Metadata
- Authors
- Wyatt, R. J.
- Affiliations
- St. Elizabeths Hospital (US)
- Corresponding author
- Wyatt, R. J.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-01-01
- Volume
- 17
- Issue
- 2
- Pages
- 325-351
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2120012268
- Cited by
- 787
- References
- 73
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 21 · 2020: 12 · 2019: 48 · 2018: 14 · 2017: 18 · 2016: 17 · 2015: 17 · 2014: 18 · 2013: 22 · 2012: 27
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- schizophrenia, antipsychotic drugs
- MeSH terms
- Humans, Recurrence, Schizophrenia, Time Factors, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
