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Cited by 32Schizophrenia research and treatmentMental Health and PsychiatryHallucinations in medical conditions

Late-onset Schizophrenia and Late Paraphrenia

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Riecher-Rossler, A., Rossler, W., Forstl, H., Meise, U.·1995·Schizophrenia Bulletin
DOI 10.1093/schbul/21.3.345
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Abstract

The term "late-onset schizophrenia" was first coined by Manfred Bleuler (1943) to describe a form of schizophrenia with an onset between the ages of 40 and 60. This concept has been adopted by German psychiatry. Until recently, British and American psychiatrists had little interest in this patient group. However, they often used the term "late-onset schizophrenia" interchangeably with late paraphrenia or as a generic term for both these diseases, even though the concept of late paraphrenia is quite different from that of late-onset schizophrenia. Late paraphrenia is a British concept that includes all delusional disorders starting after age 60. This confusion of terms and concepts is even more important now, because recent neuroimaging and neuropsychological studies suggest that an organic substrate probably exists in most cases of late paraphrenia, while only minor organic abnormalities can be found in late-onset schizophrenia. We believe it is of utmost importance to establish a clear boundary between late-onset schizophrenia and other delusional disorders in middle and old age, because the confusion in terminology and concepts is a serious impediment to comparative international research.

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  • These patients' symptoms were fundamentally similar to those in persons with earlier onset, and there were no cognitive or physical signs suggesting a degenerative brain disease.

    “These patients' symptoms were fundamentally similar to those in persons with earlier onset, and there were no cognitive or physical signs suggesting a degenerative brain disease.”

    From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [259]

  • Manfred Bleuler found that 15% of his patients with schizophrenia met this definition, with only a small number of cases presenting later.

    “He found that 15% of his patients with schizophrenia met this definition, with only a small number of cases presenting later.”

    From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [259]

  • The term 'late-onset schizophrenia' was coined by Manfred Bleuler in 1943 to describe a form of schizophrenia with an onset between the ages of 40 and 60.

    “The term “late‐onset schizophrenia” was coined by Manfred Bleuler in 1943 to describe a form of schizophrenia with an onset between the ages of 40 and 60 259 .”

    From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [259]

  • The severity of psychopathology as well as that of cognitive impairment tends to be lower in late-onset than early-onset schizophrenia, and patients with the former condition may require lower dosages of antipsychotics than age-comparable persons with the latter.

    “The severity of psychopathology as well as that of cognitive impairment tends to be lower in late‐onset than early‐onset schizophrenia 263 , and patients with the former condition may require lower dosages of antipsychotics than age‐comparable persons with the latter 259 .”

    From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [259]

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Research works printed but not linked: 33

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Related

Authors
Riecher-Rossler, A., Rossler, W., Forstl, H., & Meise, U.
Affiliations
Universität Innsbruck (AT)
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
1995-01-01
Volume
21
Issue
3
Pages
345-354
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/21.3.345
OpenAlex
W1975324212
Cited by
32
References
17
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2012: 2
FWCI
0.20
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
late-onset schizophrenia, late paraphrenia
MeSH terms
Adult, Delusions, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology

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