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Epidemiology of First-Episode Psychosis: Illustrating the Challenges Across Diagnostic Boundaries Through the Cavan-Monaghan Study at 8 Years
Abstract
The epidemiology of first-episode psychosis is poorly understood because of the paucity of systematic studies, yet it constitutes the fundamental basis for understanding the disorder and the foundations on which clinical, biological, therapeutic, and long-term outcome studies are built. A particular need is to clarify the diagnostic breadth of first-episode psychosis and, on this basis, to undertake systematic comparisons across representative populations of the psychoses, to include comparisons with first-episode mania. Considered here is the new generation of prospective studies that may be able to inform in some way on these issues. Attainment of the above goals requires prolonged accrual of "all" cases of nonaffective, affective, and any other psychotic illness, including first-episode mania, to derive the required representative populations. To illustrate some of the challenges, the structure of the Cavan-Monaghan prospective first episode study is described and its interim findings are outlined, as rural Ireland provides psychiatric care based on strict catchment areas and is characterized by substantive ethnic and socioeconomic homogeneity and stability. It is argued that there are 3 primary diagnostic nodes (schizophrenia spectrum psychosis, bipolar disorder, and major depressive disorder with psychotic features) around which there exist numerous additional, overlapping, and well-populated diagnostic categories that are distinct only in terms of their operational definition. Only through systematic, epidemiologically based studies that access this intrinsic diversity are we likely to understand fully the origins and pathobiology of first-episode psychosis.
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“People who suffer a first episode of psychosis (FEP) are frequently adolescents or young adults [1, 2]”
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Cites
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Schizophrenia and migration: A meta-analysis and review
Cantor-Graae, E., & Selten, J.-P. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.12 · Cited by 1,237
Sex Differences in the Risk of Schizophrenia: Evidence From Meta-analysis
Aleman, A., Kahn, R. S., & Selten, J.-P. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.565 · Cited by 818
Neuropsychology of bipolar disorder: a review
Quraishi, S. N., & Frangou, S. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00091-5 · Cited by 576
Duration of untreated psychosis: a critical examination of the concept and its importance
Norman, R. M. G., & MALLA, A. K. (2001) · Psychological Medicine · doi:10.1017/s0033291701003488 · Cited by 482
The McLean-Harvard First-Episode Mania Study: Prediction of Recovery and First Recurrence
Tohen, M. F., Zarate, C. A., Hennen, J. A., Khalsa, H.-M. K., Strakowski, S. M., Gebre‐Medhin, P., Salvatore, P., & Baldessarini, R. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2099 · Cited by 471
Predictors of Treatment Response From a First Episode of Schizophrenia or Schizoaffective Disorder
Robinson, D. G., Woerner, M. G., Alvir, J. M. J., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D. I., Bilder, R. M., GOLDMAN, R. S., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.544 · Cited by 466
Reducing the Duration of Untreated First-Episode Psychosis
Melle, I. S., Larsen, T. K., Haahr, U., Friis, S., Johannessen, J. O., Opjordsmoen, S., Simonsen, E. H., Rund, B. R., Vaglum, P., & McGlashan, T. H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.143 · Cited by 439
Establishing the onset of psychotic illness
Beiser, M., Erickson, D., Fleming, J. A. E., & Iacono, W. G. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.9.1349 · Cited by 373
Duration of untreated psychosis in first-episode schizophrenia: marker or determinant of course?
McGlashan, T. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00084-0 · Cited by 366
Research works printed but not linked: 7
- Chatterjee A, Lieberman JA. Studies of biological variables in first-episode schizophrenia: a comprehensive review. In: McGorry PD, Jackson HJ, eds. The Recognition and Manage- ment of Early Psychosis. Cambridge: Cambridge University Press; 1999;115-152.
- First MB, Spitzer RL, Gibbon M Structured Clinical Inter- view for DSM-IV Axis I Disorder-Patient Edition. New York: New York State Psychiatric Institute; 1998.
- Jablensky A. Schizophrenia: the epidemiological horizon. In: Hirsch SR, Weinberger DR, eds. Schizophrenia. Oxford: Blackwell Science; 1995;206-252.
- Aleman A, Kahn RS, Selton JP. Sex differences in the risk of schizophrenia. Arch Gen Psychiat 2003;60:565-571.
- Myles-Worsley M, Coon H, Tiobech J, et al. Genetic epide- miological study of schizophrenia in Palau, Micronesia. Am J Med Genet (Neuropsychiat Genet) 1999;88:4-10.
- Bellmaker RH. Bipolar disorder. N Engl J Med 2004; 351:476-486.
- Mu ¨ller-Oerlinghausen B, Bergho ¨fer A, Bauer M. Bipolar dis- order. Lancet 2002;359:241-247.
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Rowland, T., & Marwaha, S. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318769235 · Cited by 540
International incidence of psychotic disorders, 2002–17: a systematic review and meta-analysis
Jongsma, H. E., Turner, C., Kirkbride, J. B., & Jones, P. B. (2019) · The Lancet Public Health · doi:10.1016/s2468-2667(19)30056-8 · Cited by 324
Systematic Review of Early Cardiometabolic Outcomes of the First Treated Episode of Psychosis
Foley, D. L., & Morley, K. I. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2 · Cited by 283
Review of the operational definition for first‐episode psychosis
Breitborde, N. J. K., Srihari, V. H., & Woods, S. W. (2009) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2009.00148.x · Cited by 284
Diagnostic Shifts During the Decade Following First Admission for Psychosis
Bromet, E. J., Kotov, R., Fochtmann, L. J., Carlson, G. A., Tanenberg‐Karant, M., Ruggero, C. J., & Chang, S. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11010048 · Cited by 260
Metadata
- Authors
- Baldwin, P.
- Affiliations
- St. Davnet's Hospital (IE)
- Corresponding author
- Baldwin, P.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-07-27
- Volume
- 31
- Issue
- 3
- Pages
- 624-638
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1707
- OpenAlex
- W2115309432
- Cited by
- 153
- References
- 96
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 15 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 5
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stanley Medical Research Institute
- Royal College of Surgeons in Ireland
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- first-episode psychosis
- MeSH terms
- Adolescent, Adult, Aged, Diagnosis, Differential, Ethnicity, Female, Humans, Ireland, Male, Middle Aged, Terminology as Topic, Prospective Studies, Psychotic Disorders, Research Design, Social Class, Prevalence, Epidemiologic Studies
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