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Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through “Functional” (Neuro)Psychiatric Disorders
Open accessAbstract
Background: Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to a great extent on schizophrenia, and as a consequence their prevalence and featural properties in other psychiatric or neuropsychiatric disorders are poorly known. In this article, we evaluated the extent to which catatonic, extrapyramidal and neurological soft signs, and their associated clinical features, are present transdiagnostically. Methods: We examined motor-related features in neurodevelopmental (schizophrenia, obsessive compulsive disorder, autism spectrum disorders), "functional" (nonschizophrenic nonaffective psychoses, mood disorders) and neurodegenerative (Alzheimer's disease) disorders. Examination of the literature revealed that there have been very few comparisons of motor-related features across diagnoses and we had to rely mainly in disorder-specific studies to compare it transdiagnostically. Results: One or more motor domains had a substantial prevalence in all the diagnoses examined. In "functional" disorders, MAs, and particularly catatonic signs, appear to be markers of episode severity; in chronic disorders, although with different degree of strength or evidence, all motor domains are indicators of both disorder severity and poor outcome; lastly, in Alzheimer's disease they are also indicators of disorder progression. Conclusions: MAs appear to represent a true transdiagnostic domain putatively sharing neurobiological mechanisms of neurodevelopmental, functional or neurodegenerative origin.
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“The National Institute for Mental Health (NIMH), in its Research Domain Criteria (RDoC) framework matrix [76 -79], has recently proposed the incorporation of a new Sensorimotor Systems domain, composed of sub constructs such as Motor Actions, Agency and Ownership and Habits [80 -82]”
From Habit as a therapeutic component in psychological treatment for obsessive-compulsive disorder: A randomised controlled feasibility study. (2026) · cites this paper as [82]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
A network theory of mental disorders
Borsboom, D. (2017) · World Psychiatry · doi:10.1002/wps.20375 · Cited by 3,482
Kotov, R., Krueger, R. F., Watson, D., Achenbach, T. M., Althoff, R. R., Bagby, R. M., Brown, T. A., Carpenter, W. T., Caspi, A., Clark, L. A., et al. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000258 · Cited by 3,335
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,907
Manic-Depressive Insanity and Paranoia.
(1921) · JAMA · doi:10.1001/jama.1921.02630330070026 · Cited by 1,612
Diamond, A. D. (2000) · Child Development · doi:10.1111/1467-8624.00117 · Cited by 1,584
Research works printed but not linked: 32
- 1926, Les syndromes extrapiramidaus dans les maladies mentales, Arch Suiss Neurol Psychiatr, 19, 195
- 1943, Die Katatonien, Nervenarzt, 16, 1
- 2003, Catatonia. A clinicians Guide to Diagnosis and Treatment
- 1997, Katatonie Einfürung in die Phänomenologie, Klinik und Pathophysiologie eines psychomotorischen Syndroms
- 1999, Hypokinesia and hyperkinesia, 266
- Kahlbaum K, 1874, Catatonia
- 1999, Rating catatonia: discrepancy between cross-sectional and longitudinal assessment, Rev Psiq Clín, 26, 56
- 1954, The syndrome extrapyramidal et diencephalique au cours des traitments au largactil et ou serpasil, Ann Med Psychol, 112, 737
- 1928, Katatone Störungen, 134
- 1910–1911, Zur Theorie des schizophrenen Negati vismus, Psychiatrisch-Neurologische Wochenschrift, 171
- 1924, Conception neurologique du syndrome catatonique, Encephale, 19, 571
- 1969, Die Katatonie (1868–1968), Fortschr Neurol Psychiat, 37, 461
- 1995, Endogenous psychoses. Leonhard’s impact on modern psychiatry
- 2014, Manual for the classification of endogenous psychoses. 1979, International Network for the History of Neuropsychopharmacology
- 2010, DSM-IV catatonia signs and criteria in first-episode, drug-naive, psychotic patients: psychometric validity and response to antipsychotic medication, Schizophr Res, 118, 168, 10.1016/j.schres.2009.12.023 · DOI
- 2015, The diagnostic criteria and structure of catatonia, Schizophr Res, 164, 256, 10.1016/j.schres.2014.12.036 · DOI
- 1999, Motor dysfunction and risk for schizophrenia, Dev Psychopathol, 11, 509, 10.1017/S0954579499002187 · DOI
- 2012, Treatment response of neurological soft signs in drug-naïve patients with a first psychotic episode, Schizophr Res, 139, 144, 10.1016/j.schres.2012.05.019 · DOI
- 1990, Grundniss der Psychiatrie in klinischen Vorlesungen
- 1912, Die klinische Stellung der Motilitätspsychosen, Allg Z Psychiatr, 69, 109
- 2011, A comparative study of “Idiopathic catatonia” with catatonia in schizophrenia, Asian J Psychiatr, 4, 129, 10.1016/j.ajp.2011.04.007 · DOI
- 1922, Katatonishe Erscheinungen im Rahmen manish-depressiver Erkrankungen. Monographien aus dem Gesamtgebiete de Neurologie und Psychiatrie 31
- 2003, Relevance of the catatonic syndrome to the mixed manic episode, J Affect Disord, 74, 279, 10.1016/S0165-0327(02)00088-5 · DOI
- 1999, Mood-dependent tardive dyskinesia, 376
- 2015, High rates of parkinsonism in adults with autism, J Neurodevelop Dis, 7, 1
- 1996, A Disorder of Movement and Mood
- 1960, Über kindliche Katatonien, Psychiatr Neurol Med Psychol, 12, 1
- 1932, Syndromes d’insuffisance psychomotrice et types psycho-moteurs, 240
- 1910, Débilité mentale et débilité motrice asocies, Rev Neurol, 20, 54
- 2010, Paratonia (gegenhalten), 376
- 2004, Genetics, 173
- 2000, Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15, Am J Hum Genet, 67, 1201, 10.1016/S0002-9297(07)62950-4 · DOI
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Maj, M., van Os, J., De Hert, M., Gaebel, W., Galderisi, S., Green, M. F., Guloksuz, S., Harvey, P. D., Jones, P. B., Malaspina, D., et al. (2021) · World Psychiatry · doi:10.1002/wps.20809 · Cited by 285
Smeland, O. B., Shadrin, A. A., Bahrami, S., Broce, I., Tesli, M., Frei, O., Wirgenes, K. V., O’Connell, K. S., Krull, F., Bettella, F., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.026 · Cited by 98
“The findings indicate that in some patients, genetic variants shared by SCZ and PD may possibly contribute to overlapping clinical and pathophysiological features between the disorders, for example dyskinesia and parkinsonism in antipsychotic-naïve SCZ patients (8, 9).”
BackgroundThe utility of an RDoC motor domain to understand psychomotor symptoms in depression
Walther, S., Bernard, J. A., Mittal, V. A., & Shankman, S. A. (2018) · Psychological Medicine · doi:10.1017/s0033291718003033 · Cited by 90
“This lack of rigorous measures for motor disturbances in depression is particularly surprising for a core feature of the disease, as motor markers have been highly predictive and intimately tied to disease and course in other disorders such a psychosis, autism, and dementia (Scarmeas et al., 2004; Jansiewicz et al., 2…”
BackgroundSystems Neuroscience of Psychosis: Mapping Schizophrenia Symptoms onto Brain Systems
Strik, W. K., Stegmayer, K., Walther, S., & Dierks, T. (2017) · Neuropsychobiology · doi:10.1159/000485221 · Cited by 82
Walther, S., van Harten, P. N., Waddington, J. L., Cuesta, M. J., Peralta, V., Dupin, L., Foucher, J., Sambataro, F., Morrens, M., Kubera, K. M., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.07.003 · Cited by 74
Metadata
- Authors
- Peralta, V., & Cuesta, M. J.
- Affiliations
- Complejo Hospitalario de Navarra (ES)
- ORCID
- Cuesta, Manuel J
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-22
- Volume
- 43
- Issue
- 5
- Pages
- 956-971
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC5581892
- OpenAlex
- W2737738292
- Cited by
- 133
- References
- 251
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 5 · 2023: 11 · 2022: 16 · 2021: 20 · 2020: 21 · 2019: 8 · 2018: 13 · 2017: 9
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III (PI16/02148)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- motor abnormalities, transdiagnostic markers
- MeSH terms
- Autism Spectrum Disorder, Alzheimer Disease, Humans, Movement Disorders, Obsessive-Compulsive Disorder, Psychotic Disorders, Schizophrenia, Mood Disorders
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