The acute effects of nefazodone, trazodone and buspirone on sleep and sleep‐related penile tumescence in normal subjects
Abstract
This study examined the effects of nefazodone, trazodone and buspirone on sleep and sleep-related penile tumescence. Trazodone is a sedating antidepressant without anticholinergic properties. Nefazodone is a new antidepressant that is a structural analogue of trazodone but is less sedating. Buspirone is a nonsedating, nonbenzodiazepine anxiolytic with antidepressant properties. Nefazodone was compared to trazodone and buspirone in a double-blind, placebo-controlled crossover study in 12 normal healthy males. Nefazodone increased rapid eye movement (REM) sleep, whereas trazodone and buspirone suppressed REM sleep. The drugs only minimally affected other sleep stages. Trazodone increased total tumescence time by delaying the onset of detumescence; nefazodone increased total tumescence time only insofar as it increased REM sleep; buspirone did not change total tumescence time when compared to placebo. The results support a growing body of data indicating that not all antidepressants suppress REM sleep. The results also are consistent with the interpretation of an earlier study showing that trazodone prolongs penile tumescence during sleep as a result of its alpha-adrenergic blocking properties that suppress detumescence. Nefazodone, with less alpha-adrenergic blocking activity, did not abnormally penile tumescence beyond REM sleep.
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Significantly more REM sleep suppression was observed with trazodone (100mg) than with nefazodone (200mg).
“(Ware et al., 1994) observed significantly more REM sleep suppression with trazodone (100mg) than with nefazodone (200mg).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Ware et al., 1994
In healthy volunteers, nefazodone 200mg significantly increased REM% compared to placebo, while trazodone 100mg and buspirone 10mg significantly decreased REM% compared to placebo.
“NEF sig more REM% than PLC, but TRZ & BUS sig less REM% than PLC”
From Antidepressants and their effect on sleep (2005) · cites this paper as Ware, 1994
In healthy volunteers, trazodone 100mg caused significantly fewer WASO than placebo.
“TRZ sig fewer WASO than PLC”
From Antidepressants and their effect on sleep (2005) · cites this paper as Ware, 1994
In healthy volunteers, nefazodone 200mg caused significantly less % stage 2 sleep than all other groups, and significantly less stage 3% than trazodone and buspirone.
“NEF sig less % stage 2 sleep than all other groups, sig less stage 3% than TRZ and BUS”
From Antidepressants and their effect on sleep (2005) · cites this paper as Ware, 1994
In healthy volunteers, trazodone 100mg and buspirone 10mg significantly lengthened REM latency compared to nefazodone 200mg and placebo (all p=.05).
“TRZ & BUS sig longer REML than NEF and than PLC (all sig post-hoc comparisons to p=.05)”
From Antidepressants and their effect on sleep (2005) · cites this paper as Ware, 1994
In another study, trazodone suppressed REM sleep, while nefazodone increased REM sleep.
“In another study, trazodone suppressed REM sleep, while nefazodone increased REM sleep [Ware et al., 1994].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Ware et al., 1994
The most consistently reported effect of trazodone on sleep in depressed patients was REM suppression, expressed as either decreased REM time or REM percentage, or increased REM latency.
“The most consistently reported effect of trazodone on sleep in depressed patients was REM suppression, expressed as either decreased REM time or REM percentage, or increased REM latency [Mouret et al., 1988;Ware et al., 1994;van Bemmel and Havermans, 1992;Scharf and Sachais, 1990].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Ware et al., 1994
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Recommendations for a standard research assessment of insomnia
Buysse, D. J., Ancoli-Israel, S., Edinger, J. D., Lichstein, K. L., & Morin, C. M. (2006) · Sleep · doi:10.1093/sleep/29.9.1155 · Cited by 1,206 · see citing works
Antidepressants and their effect on sleep
Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323 · see citing works
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Depression, sleep physiology, and antidepressant drugs
Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179 · see citing works
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- Authors
- Ware, J. C., Rose, F. V., & McBrayer, R. H.
- Affiliations
- Eastern Virginia Medical School (US)
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-09
- Volume
- 17
- Issue
- 6
- Pages
- 544-550
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2410502223
- Cited by
- 56
- References
- 0
- Citations by year
- 2023: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2012: 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- nefazodone, trazodone, buspirone, REM sleep suppression, antidepressants, alpha-adrenergic blockade, detumescence, sleep stages, healthy men
- MeSH terms
- Adult, Analysis of Variance, Antidepressive Agents, Buspirone, Double-Blind Method, Humans, Male, Penile Erection, Piperazines, Reference Values, Sleep, Trazodone, Triazoles
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