The DOI matches its Crossref record.
The Effects of Caffeine on Simulated Night-Shift Work and Subsequent Daytime Sleep
Abstract
Thirty healthy volunteers were randomly assigned to either a caffeine or a placebo group to investigate the alerting effects of caffeine at night. Subjects adhered to a simulated night-shift schedule for 5 consecutive nights. On the first 3 nights, 2 mg/kg caffeine was added to decaffeinated coffee at 2220 and 0120 hours for the caffeine group. On nights 4 and 5 both groups received placebo. Each night, subjects completed five 60-minute sessions of a computerized simulated assembly line performance task (SALT), a multiple sleep latency test (MSLT) and questionnaires. Daytime sleep was recorded in the laboratory between 0900 and 1700 hours each day following nighttime testing. Caffeine decreased physiological sleep tendency on the night shift compared with placebo; however, the two groups performed at equivalent levels on the SALT. On nights 4 and 5, when both groups received placebo, there were no differences between the groups on the MSLT, suggesting the absence of a discontinuation effect. There were no differences on daytime polysomnograms between the groups.
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“Melatonin appears to improve adaptation to day-time sleep schedules and increases the length of sleep16,17.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [17]
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Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030
Effects of caffeine on human behavior
Smith, A. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00096-0 · Cited by 741
“The ability of caffeine to counteract the effects of fatigue has been confirmed using simulations of driving (Horne and Reyner, 1996; Reyner and Horne, 1997 ) and also simulated assemblyline work (Muehlbach and Walsh, 1995).”
BackgroundCircadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders
Sack, R. L., Auckley, D., Auger, R. R., Carskadon, M. A., Wright, K. P., Vitiello, M. V., & Zhdanova, I. V. (2007) · Sleep · doi:10.1093/sleep/30.11.1460 · Cited by 650
Sleep loss and fatigue in shift work and shift work disorder
Åkerstedt, T., & Wright, K. P. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.03.001 · Cited by 639
“No study to date has been performed to document the incidence of pathological sleepiness in shift workers at night, but data from simulated shift work studies suggest that average MSLT sleep latencies are lower during the biological night(53;54).”
Background
Metadata
- Authors
- Muehlbach, M. J., & Walsh, J. K.
- Affiliations
- St. Luke's Hospital (US)
- Corresponding author
- Muehlbach, Mark J.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-01
- Volume
- 18
- Issue
- 1
- Pages
- 22-29
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W167991554
- Cited by
- 122
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 1 · 2012: 8
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- caffeine, night shift work, circadian misalignment, daytime sleep, alertness, multiple sleep latency test, caffeine withdrawal, shift work
- MeSH terms
- Adult, Body Weight, Caffeine, Circadian Rhythm, Female, Humans, Male, Placebos, Surveys and Questionnaires, Sleep, Task Performance and Analysis, Wakefulness, Work
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