Prostaglandin D Synthase (β-trace) in Healthy Human Sleep
Abstract
STUDY OBJECTIVES: The prostaglandin D system plays an important role in animal sleep. In humans, alterations in the prostaglandin D system have been found in diseases exhibiting sleep disturbances as a prominent symptom, such as trypanosoma infection, systemic mastocytosis, bacterial meningitis, major depression, or obstructive sleep apnea. Assessment of this system's activity in relation to human physiologic sleep was the target of the present study. DESIGN: Serum concentrations of lipocalin-type prostaglandin D synthase (L-PGDS, former beta-trace), and plasma levels of the pineal hormone melatonin were measured in 20 healthy humans (10 women, 10 men; aged: 23.3 +/- 2.39 years) at 4-hour intervals over a period of 5 days and nights, which included physiologic sleep, rapid eye movement sleep deprivation, and total sleep deprivation. In addition, the serum L-PGDS and plasma melatonin levels of 6 subjects were determined under conditions of bright white (10,000 lux) or dark red light (< 50 lux) in a crossover design during total sleep deprivation. Nocturnal blood sampling was performed by a through-the-wall tube system. L-PGDS was measured by an automated immunonephelometric assay, and melatonin was analyzed by direct radioimmunoassay. RESULTS: Serum L-PGDS concentrations showed marked time-dependent changes with evening increases and the highest values at night (P < .0005). This nocturnal increase was suppressed during total sleep deprivation (P < .05), independent of external light conditions and melatonin secretion. Rapid eye movement sleep deprivation had no impact on circulating L-PGDS levels. CONCLUSIONS: The circadian L-PGDS pattern and its suppression by total sleep deprivation indicate an interaction of the prostaglandin D system and human sleep regulation. L-PGDS measurements may well provide new insights into physiologic and pathologic sleep regulation in humans.
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- Authors
- Jordan, W., Tumani, H., Cohrs, S., Eggert, S., Rodenbeck, A., Brunner, E., Rüther, E., & Hajak, G.
- Affiliations
- University of Göttingen (DE)
- Universität Ulm (DE)
- University of Regensburg (DE)
- Corresponding author
- Jordan, Wolfgang
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08
- Volume
- 27
- Issue
- 5
- Pages
- 867-874
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W115019212
- Cited by
- 56
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- GRO (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- prostaglandin D synthase, lipocalin-type prostaglandin D synthase, melatonin, sleep regulation, circadian rhythm, total sleep deprivation, REM sleep deprivation, light exposure
- MeSH terms
- Adult, Circadian Rhythm, Female, Humans, Disorders of Excessive Somnolence, Light, Male, Melatonin, Radioimmunoassay, Sleep, Sleep Deprivation, Sleep Stages, Wakefulness, Cross-Over Studies, Intramolecular Oxidoreductases, Lipocalins
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