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Cited by 345

The DOI matches its Crossref record; 511 of the 511 references it cites were found in a registry or an index.

Molecular Signatures of Obstructive Sleep Apnea in Adults: A Review and Perspective

Open access
Arnardottir, Erna S., Mackiewicz, Miroslaw, Gislason, Thorarinn, Teff, Karen L., Pack, Allan I.·2009·Sleep
DOI 10.1093/sleep/32.4.447
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Abstract

The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are sympathetic activity, oxidative stress and inflammation. Other affected domains include adipokines, adhesion molecules and molecules that respond to endoplasmic reticulum stress. Changes in molecular domains affected by OSA, assessed in blood and/or urine, can provide a molecular signature for OSA that could potentially be used diagnostically and to predict who is likely to develop different OSA-related comorbidities. High-throughput discovery strategies such as microarrays, assessing changes in gene expression in circulating blood cells, have the potential to find new candidates and pathways thereby expanding the molecular signatures for OSA. More research is needed to fully understand the pathophysiological significance of these molecular signatures and their relationship with OSA comorbidities. Many OSA subjects are obese, and obesity is an independent risk factor for many comorbidities associated with OSA. Moreover, obesity affects the same molecular pathways as OSA. Thus, a challenge to establishing a molecular signature for OSA is to separate the effects of OSA from obesity. We propose that the optimal strategy is to evaluate the temporal changes in relevant molecular pathways during sleep and, in particular, the alterations from before to after sleep when assessed in blood and/or urine. Such changes will be at least partly a consequence of chronic intermittent hypoxia and sleep fragmentation that occurs during sleep.

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Metadata

Authors
Arnardottir, E. S., Mackiewicz, M., Gislason, T., Teff, K. L., & Pack, A. I.
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2009-04
Volume
32
Issue
4
Pages
447-470
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/32.4.447
OpenAlex
W26912437
Cited by
345
References
511
FWCI
14.17
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Molecular Signatures of Obstructive Sleep Apnea in Adults: A Review and Perspective. https://app.cochat.ai/papers/10.1093/sleep/32.4.447
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Arnardottir, E. S., Mackiewicz, M., Gislason, T., Teff, K. L., & Pack, A. I. (2009). Molecular Signatures of Obstructive Sleep Apnea in Adults: A Review and Perspective. Sleep. https://doi.org/10.1093/sleep/32.4.447

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.