The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
Therapeutic potential of intermittent hypoxia: a matter of dose
Open accessAbstract
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and triggers a bewildering array of both detrimental and beneficial effects in multiple physiological systems. Here, we review the extensive literature concerning IH and its impact on the respiratory, cardiovascular, immune, metabolic, bone, and nervous systems. One major goal is to define relevant IH characteristics leading to safe, protective, and/or therapeutic effects vs. pathogenesis. To understand the impact of IH, it is essential to define critical characteristics of the IH protocol under investigation, including potentially the severity of hypoxia within episodes, the duration of hypoxic episodes, the number of hypoxic episodes per day, the pattern of presentation across time (e.g., within vs. consecutive vs. alternating days), and the cumulative time of exposure. Not surprisingly, severe/chronic IH protocols tend to be pathogenic, whereas any beneficial effects are more likely to arise from modest/acute IH exposures. Features of the IH protocol most highly associated with beneficial vs. pathogenic outcomes include the level of hypoxemia within episodes and the number of episodes per day. Modest hypoxia (9–16% inspired O 2 ) and low cycle numbers (3–15 episodes per day) most often lead to beneficial effects without pathology, whereas severe hypoxia (2–8% inspired O 2 ) and more episodes per day (48–2,400 episodes/day) elicit progressively greater pathology. Accumulating evidence suggests that “low dose” IH (modest hypoxia, few episodes) may be a simple, safe, and effective treatment with considerable therapeutic potential for multiple clinical disorders.
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Pericytes impair capillary blood flow and motor function after chronic spinal cord injury
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Metadata
- Authors
- Navarrete-Opazo, A., & Mitchell, G. S.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2014-11-15
- Volume
- 307
- Issue
- 10
- Pages
- R1181-R1197
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2033337525
- Cited by
- 469
- References
- 218
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- green
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