The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Review of the Relationship of Restless Legs Syndrome and Periodic Limb Movements in Sleep to Hypertension, Heart Disease, and Stroke
Open accessAbstract
Evidence is reviewed documenting an intimate relationship among restless legs syndrome (RLS) / periodic limb movements in sleep (PLMS) and hypertension and cardiovascular and cerebrovascular disease. Sympathetic overactivity is associated with RLS/PLMS, as manifested by increased pulse rate and blood pressure coincident with PLMS. Causality is far from definitive. Mechanisms are explored as to how RLS/PLMS may lead to high blood pressure, heart disease, and stroke: (a) the sympathetic hyperactivity associated with RLS/PLMS may lead to daytime hypertension that in turn leads to heart disease and stroke; (b) in the absence of daytime hypertension, this sympathetic hyperactivity may predispose to heart disease and stroke either directly or indirectly via atherosclerotic plaque formation and rupture; and (c) comorbidities associated with RLS/PLMS, such as renal failure, diabetes, iron deficiency, and insomnia, may predispose to heart disease and stroke. One theoretical cause for sympathetic hyperactivity is insufficient All diencephalospinal dopaminergic neuron inhibition of sympathetic preganglionic neurons residing in the intermediolateral cell columns of the spinal cord. We cannot exclude the possibility that peripheral vascular, cardiovascular, and cerebrovascular disease may also contribute to RLS/PLMS, and mechanisms for these possibilities are also discussed.
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Cited by
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
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Sleep and COVID-19: considerations about immunity, pathophysiology, and treatment.
(2020) · PubMed Central · doi:10.5935/1984-0063.20200062 · Cited by 77
Relationship between Sleep Disorders and the Risk for Developing Type 2 Diabetes Mellitus
Ioja, S., Weir, I. D., & Rennert, N. J. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.07.2573 · Cited by 32
Xie, J., Chahal, C. A. A., Covassin, N., Schulte, P. J., Singh, P., Srivali, N., Somers, V. K., & Caples, S. M. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.04.060 · Cited by 22
Metadata
- Authors
- Walters, A. S., & Rye, D. B.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05
- Volume
- 32
- Issue
- 5
- Pages
- 589-597
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W1821797520
- Cited by
- 425
- References
- 67
- FWCI
- 19.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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