The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery
Abstract
Study Objectives: Sleep is vital for brain development and healing after injury, placing children with sleep-wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other posttraumatic outcomes. Methods: Systematic searches were conducted in MEDLINE, PsychINFO, and reference lists for English language articles published from 1999 to 2019 evaluating sleep or fatigue in children hospitalized for mild complicated, moderate, or severe TBI. Two independent reviewers assessed eligibility, extracted data, and assessed risk of bias using the Newcastle–Ottowa Score for observational studies. Results: Among 966 articles identified in the search, 126 full-text articles were reviewed, and 24 studies were included (11 prospective, 9 cross-sectional, and 4 case studies). Marked heterogeneity was found in study populations, measures defining SWD, and time from injury to evaluation. Studies showed at least 20% of children with TBI had trouble falling or staying asleep, fatigue, daytime sleepiness, and nightmares. SWD are negatively correlated with posttraumatic cognitive, behavioral, and quality of life outcomes. No comparative intervention studies were identified. The risk of bias was moderate–high for all studies often related to lack of validated or objective SWD measures and small sample size. Heterogeneity precluded meta-analyses. Conclusions: SWD are important morbidities after pediatric TBI, though current data are limited. SWD have implications for TBI recovery and may represent a modifiable target for improving outcomes after pediatric TBI.
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Chronic Aspects of Pediatric Traumatic Brain Injury: Review of the Literature
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Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies
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Childhood sleep: assessments, risk factors, and potential mechanisms
Liu, J., Ji, X., Rovit, E., Pitt, S., & Lipman, T. H. (2022) · World Journal of Pediatrics · doi:10.1007/s12519-022-00628-z · Cited by 35
Turner, A. D., Sullivan, T. M., Drury, K. M., Hall, T. A., Williams, C. N., Guilliams, K. P., Murphy, S. A., & O'Meara, A. M. I. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.713668 · Cited by 35
Self-citationDjukic, S., Phillips, N. L., & Lah, S. (2022) · Brain Injury · doi:10.1080/02699052.2022.2140198 · Cited by 26
Roberts, S., Owen, P. J., Warmington, S. A., Trevenen, J., Caeyenberghs, K., McDonald, S. J., Facer‐Childs, E. R., McKay, A., Bradshaw, E., Kara, S., et al. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102072 · Cited by 22
Alyenbaawi, H., Allison, W. T., & Mok, S. (2020) · Biomolecules · doi:10.3390/biom10111487 · Cited by 20
Metadata
- Authors
- Luther, M., Poppert Cordts, K. M., & Williams, C. N.
- Affiliations
- Oregon Health & Science University (US)
- Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-04-24
- Volume
- 43
- Issue
- 10
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W3018210770
- Cited by
- 34
- References
- 51
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (K12HS022981)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- sleep disorders, pediatric traumatic brain injury, sleep-wake disturbances, fatigue, daytime sleepiness, nightmares, prevalence, risk factors, cognitive outcomes, behavioral effects, quality of life, sleep interventions
- MeSH terms
- Brain Injuries, Traumatic, Child, Cross-Sectional Studies, Humans, Prospective Studies, Quality of Life, Risk Factors, Sleep, Prevalence
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
