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Cited by 673Dementia and Cognitive Impairment ResearchSleep and related disordersObstructive Sleep Apnea Research

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Sleep, Cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis

Bubu, Omonigho M., Brannick, Michael, Mortimer, James, Umasabor-Bubu, Ogie, Sebastião, Yuri V., Wen, Yi, Schwartz, Skai, Borenstein, Amy R., Wu, Yougui, Morgan, David, Anderson, William M.·2017·Sleep
DOI 10.1093/sleep/zsw032
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Abstract

Study Objectives: Mounting evidence implicates disturbed sleep or lack of sleep as one of the risk factors for Alzheimer's disease (AD), but the extent of the risk is uncertain. We conducted a broad systematic review and meta-analysis to quantify the effect of sleep problems/disorders on cognitive impairment and AD. Methods: Original published literature assessing any association of sleep problems or disorders with cognitive impairment or AD was identified by searching PubMed, Embase, Web of Science, and the Cochrane library. Effect estimates of individual studies were pooled and relative risks (RR) and 95% confidence intervals (CI) were calculated using random effects models. We also estimated the population attributable risk. Results: Twenty-seven observational studies (n = 69216 participants) that provided 52 RR estimates were included in the meta-analysis. Individuals with sleep problems had a 1.55 (95% CI: 1.25-1.93), 1.65 (95% CI: 1.45-1.86), and 3.78 (95% CI: 2.27-6.30) times higher risk of AD, cognitive impairment, and preclinical AD than individuals without sleep problems, respectively. The overall meta-analysis revealed that individuals with sleep problems had a 1.68 (95% CI: 1.51-1.87) times higher risk for the combined outcome of cognitive impairment and/or AD. Approximately 15% of AD in the population may be attributed to sleep problems. Conclusion: This meta-analysis confirmed the association between sleep and cognitive impairment or AD and, for the first time, consolidated the evidence to provide an "average" magnitude of effect. As sleep problems are of a growing concern in the population, these findings are of interest for potential prevention of AD.

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Show all 71 references

Research works printed but not linked: 4

  1. 2000, Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group, JAMA, 283(15), 2008
  2. Inc. SI. SAS 9.4 System, 2013, Guide to Software Updates
  3. 2010, Conducting meta-analyses in R with the metafor package, J Stat Soft, 36(3), 1
  4. 2014, [Obstructive sleep apnea syndrome: a cause of cognitive disorders in the elderly?], Rev Med Interne, 35, 664

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Metadata

Authors
Bubu, O. M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebastião, Y. V., Wen, Y., Schwartz, S., Borenstein, A. R., Wu, Y., Morgan, D., & Anderson, W. M.
Affiliations
University of South Florida (US)
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2016-12-09
Volume
40
Issue
1
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/zsw032
OpenAlex
W2547784142
Cited by
673
References
71
Citations by year
2026: 80 · 2025: 100 · 2024: 116 · 2023: 84 · 2022: 80 · 2021: 73 · 2020: 62 · 2019: 44 · 2018: 19 · 2017: 14
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Locations
  • SLEEP (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Keywords
sleep disorders, Alzheimer's disease, cognitive impairment, preclinical Alzheimer's disease, risk factors, population attributable risk, dementia prevention
MeSH terms
Alzheimer Disease, Humans, Risk Factors, Sleep Wake Disorders, Cognitive Dysfunction

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