Cited by 673Dementia and Cognitive Impairment ResearchSleep and related disordersObstructive Sleep Apnea Research

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Sleep, Cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis

Bubu, Omonigho M., Brannick, Michael, Mortimer, James, Umasabor-Bubu, Ogie, Sebastião, Yuri V., Wen, Yi, Schwartz, Skai, Borenstein, Amy R., Wu, Yougui, Morgan, David, Anderson, William M.·2017·Sleep

DOI 10.1093/sleep/zsw032

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Abstract

Study Objectives: Mounting evidence implicates disturbed sleep or lack of sleep as one of the risk factors for Alzheimer's disease (AD), but the extent of the risk is uncertain. We conducted a broad systematic review and meta-analysis to quantify the effect of sleep problems/disorders on cognitive impairment and AD. Methods: Original published literature assessing any association of sleep problems or disorders with cognitive impairment or AD was identified by searching PubMed, Embase, Web of Science, and the Cochrane library. Effect estimates of individual studies were pooled and relative risks (RR) and 95% confidence intervals (CI) were calculated using random effects models. We also estimated the population attributable risk. Results: Twenty-seven observational studies (n = 69216 participants) that provided 52 RR estimates were included in the meta-analysis. Individuals with sleep problems had a 1.55 (95% CI: 1.25-1.93), 1.65 (95% CI: 1.45-1.86), and 3.78 (95% CI: 2.27-6.30) times higher risk of AD, cognitive impairment, and preclinical AD than individuals without sleep problems, respectively. The overall meta-analysis revealed that individuals with sleep problems had a 1.68 (95% CI: 1.51-1.87) times higher risk for the combined outcome of cognitive impairment and/or AD. Approximately 15% of AD in the population may be attributed to sleep problems. Conclusion: This meta-analysis confirmed the association between sleep and cognitive impairment or AD and, for the first time, consolidated the evidence to provide an "average" magnitude of effect. As sleep problems are of a growing concern in the population, these findings are of interest for potential prevention of AD.

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Authors: Bubu, O. M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebastião, Y. V., Wen, Y., Schwartz, S., Borenstein, A. R., Wu, Y., Morgan, D., & Anderson, W. M.
Affiliations: University of South Florida (US)
ORCID: Bubu, Omonigho M.
Brannick, Michael
Sebastião, Yuri V.
Wen, Yi
Wu, Yougui
Morgan, David
Venue: Sleep
Publisher: Oxford University Press (OUP)
Published: 2016-12-09
Volume: 40
Issue: 1
ISSN: 0161-8105 (ISSN-L)
1550-9109
DOI: 10.1093/sleep/zsw032
OpenAlex: W2547784142
Cited by: 673
References: 71
Citations by year: 2026: 80 · 2025: 100 · 2024: 116 · 2023: 84 · 2022: 80 · 2021: 73 · 2020: 62 · 2019: 44 · 2018: 19 · 2017: 14
FWCI: 3.66
Type: journal article
Language: en
Open access: closed
Locations: SLEEP (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Keywords: sleep disorders, Alzheimer's disease, cognitive impairment, preclinical Alzheimer's disease, risk factors, population attributable risk, dementia prevention
MeSH terms: Alzheimer Disease, Humans, Risk Factors, Sleep Wake Disorders, Cognitive Dysfunction

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Sleep, Cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis

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