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Metabonomics in Toxicology: A Review
Abstract
Metabonomics and its many pseudonyms (metabolomics, metabolic profiling, etc.) have exploded onto the scientific scene in the past 2 to 3 years. Nowhere has the impact been more profound than within the toxicology community. Within this community there exists a great deal of uncertainty about whether metabonomics is something to count on or just the most recent technological flash in the pan. Much of the uncertainty is due to unfamiliarity with analytical and chemometric facets of the technology and the attendant fear of any "black-box." With those fears in mind, metabonomics technology is reviewed with particular emphasis on toxicologic applications in preclinical drug development. The jargon, logistics, and applications of the technology are covered in some detail with emphasis on recent work in the field.
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Cited by
The model organism as a system: integrating 'omics' data sets
Joyce, A. R., & Palsson, B. Ø. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1857 · Cited by 785
Zhou, B., Xiao, J. F., Tuli, L., & Ressom, H. W. (2011) · Molecular BioSystems · doi:10.1039/c1mb05350g · Cited by 639
Jordan, S. A., Cunningham, D. G., & Marles, R. J. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.12.005 · Cited by 415
Systems Toxicology: From Basic Research to Risk Assessment
Sturla, S. J., Boobis, A. R., FitzGerald, R. E., Hoeng, J., Kavlock, R. J., Schirmer, K., Whelan, M., Wilks, M. F., & Peitsch, M. C. (2014) · Chemical Research in Toxicology · doi:10.1021/tx400410s · Cited by 366
Systems biology, metabolic modelling and metabolomics in drug discovery and development
Kell, D. B. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.10.004 · Cited by 297
Metadata
- Authors
- Robertson, D. G.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-02
- Volume
- 85
- Issue
- 2
- Pages
- 809-822
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2163617578
- Cited by
- 541
- References
- 0
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
