The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
Abstract
Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity are highlighted.
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Citations
Cites
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
Westerfield, M. (1995) · Medical Entomology and Zoology · Cited by 6,813
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Effective targeted gene ‘knockdown’ in zebrafish
Nasevicius, A., & Ekker, S. C. (2000) · Nature Genetics · doi:10.1038/79951 · Cited by 2,483
In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish
Lawson, N. D., & Weinstein, B. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0711 · Cited by 2,151
Haffter, P., Granato, M., Brand, M., Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., J. M. van Eeden, F., Jiang, Y.-J., Heisenberg, C.-P., et al. (1996) · Development · doi:10.1242/dev.123.1.1 · Cited by 1,662
Stages of normal development in the medaka Oryzias latipes
Iwamatsu, T. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.03.012 · Cited by 1,200
Morpholino Antisense Oligomers: Design, Preparation, and Properties
SUMMERTON, J., & WELLER, D. (1997) · Antisense and Nucleic Acid Drug Development · doi:10.1089/oli.1.1997.7.187 · Cited by 1,116
Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor
Hoffman, E. C., Reyes, H., Chu, F.-F., Sander, F., Conley, L. H., Brooks, B. A., & Hankinson, O. (1991) · Science · doi:10.1126/science.1852076 · Cited by 957
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
Cited by
Lee, K. J., Nallathamby, P. D., Browning, L. M., Osgood, C. J., & Xu, X.-H. N. (2007) · ACS Nano · doi:10.1021/nn700048y · Cited by 724
The husbandry of zebrafish (Danio rerio): A review
Lawrence, C. (2007) · Aquaculture · doi:10.1016/j.aquaculture.2007.04.077 · Cited by 715
Alternatives to animal testing: a review
Doke, S. K., & Dhawale, S. C. (2015) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.11.002 · Cited by 564
An ecotoxicological characterization of nanocrystalline cellulose (NCC)
Kovacs, T., Naish, V., O'Connor, B., Blaise, C., Gagné, F., Hall, L., Trudeau, V., & Martel, P. (2010) · Nanotoxicology · doi:10.3109/17435391003628713 · Cited by 269
Hahn, M. E., Karchner, S. I., Evans, B. R., Franks, D. G., Merson, R. R., & Lapseritis, J. M. (2006) · Journal of Experimental Zoology Part A: Comparative Experimental Biology · doi:10.1002/jez.a.323 · Cited by 153
Metadata
- Authors
- Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-09
- Volume
- 86
- Issue
- 1
- Pages
- 6-19
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2158406641
- Cited by
- 1,374
- References
- 145
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E. (2005). Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfi110
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.