The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
Abstract
Various chemicals found in the human and wildlife environments have the potential to disrupt endocrine functions in exposed organisms. Increasingly, the enzymes involved in the steroid biosynthesis pathway are being recognized as important targets for the actions of various endocrine-disrupting chemicals. Interferences with steroid biosynthesis may result in impaired reproduction, alterations in (sexual) differentiation, growth, and development and the development of certain cancers. Steroid hormone synthesis is controlled by the activity of several highly substrate-selective cytochrome P450 enzymes and a number of steroid dehydrogenases and reductases. Particularly aromatase (CYP19), the enzyme that converts androgens to estrogens, has been the subject of studies into the mechanisms by which chemicals interfere with sex steroid hormone homeostasis and function, often related to (de)feminization and (de)masculinazation processes. Studies in vivo and in vitro have focussed on ovarian and testicular function, with less attention given to other steroidogenic organs, such as the adrenal cortex. This review aims to provide a comprehensive overview of the state of knowledge regarding the mechanisms by which chemicals interfere with the function of steroidogenic enzymes in various tissues and organisms. The endocrine toxicities and mechanisms of action related to steroidogenesis of a number of classes of drugs and environmental contaminants are discussed. In addition, several potential in vitro bioassays are reviewed for their usefulness as screening tools for the detection of chemicals that can interfere with steroidogenesis. Analysis of the currently scattered state of knowledge indicates that still relatively little is known about the underlying mechanisms of interference of chemicals with steroidogenesis and their potential toxicity in steroidogenic tissues, neither in humans nor in wildlife. Considerably more detailed and systematic research in this area of (endocrine) toxicology is required for a better understanding of risks to humans and wildlife.
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Citations
Cites
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
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“3b-HSD is widely distributed in steroidogenic and nonsteroidogenic tissues and consists of two isoenzymes, which are regulated in a tissue-specific manner (Gingras et al., 2001; Leers-Sucheta et al., 1997; Mason et al., 1997; Simard et al., 2005).”
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The role of 17 beta-hydroxysteroid dehydrogenases
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Cited by
Giulivo, M., Lopez de Alda, M., Capri, E., & Barceló, D. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.011 · Cited by 573
Shanle, E. K., & Xu, W. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100231n · Cited by 522
Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods
Guo, W., Pan, B., Sakkiah, S., Yavas, G., Ge, W., Zou, W., Tong, W., & Hong, H. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16224361 · Cited by 435
Exposure to endocrine disruptors during adulthood: consequences for female fertility
Rattan, S., Zhou, C., Chiang, C., Mahalingam, S., Brehm, E., & Flaws, J. A. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0023 · Cited by 339
Mousavi, S. E., Amini, H., Heydarpour, P., Amini Chermahini, F., & Godderis, L. (2019) · Environment International · doi:10.1016/j.envint.2018.11.052 · Cited by 202
Metadata
- Authors
- Sanderson, J. T.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-27
- Volume
- 94
- Issue
- 1
- Pages
- 3-21
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2126168000
- Cited by
- 517
- References
- 9
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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