Cited by 361Sexual Differentiation and DisordersSteroid Chemistry and BiochemistryAdrenal Hormones and Disorders

The role of 17 beta-hydroxysteroid dehydrogenases

Mindnich, R, Möller, G, Adamski, J·2004·Molecular and Cellular Endocrinology

Abstract

The biological activity of steroid hormones is regulated at the pre-receptor level by several enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta -HSD). The latter are present in many microorganisms, invertebrates and vertebrates. Dysfunctions in human 17 beta-hydroxysteroid dehydrogenases result in disorders of biology of reproduction and neuronal diseases, the enzymes are also involved in the pathogenesis of various cancers. 17 beta-hydroxysteroid dehydrogenases reveal a remarkable multifunctionality being able to modulate concentrations not only of steroids but as well of fatty and bile acids. Current knowledge on genetics, biochemistry and medical implications is presented in this review.

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Registry

Crossref · 10.1016/j.mce.2003.12.006

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189 of 189 references verified0 citation errors · 0 not checkable

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Authors
Mindnich, R., Möller, G., & Adamski, J.
Affiliations
Helmholtz Munich (DE)
Corresponding author
Adamski, J
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2004-04
Volume
218
Issue
1-2
Pages
7-20
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2083859759
Cited by
354
References
203
Citations by year
2026: 7 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 13 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 14 · 2013: 8 · 2012: 10
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
17β-hydroxysteroid dehydrogenase, steroid hormone metabolism, steroidogenesis, reproductive disorders, neuronal diseases, carcinogenesis, fatty acid metabolism, bile acid metabolism, enzyme genetics, enzyme biochemistry
MeSH terms
Androgens, Animals, Estrogens, Humans, 17-Hydroxysteroid Dehydrogenases, Molecular Structure

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