The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats
Abstract
Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a potent antibacterial and antifungal compound that is widely used in personal care products, plastics, and fabrics. Recently triclosan has been shown to alter endocrine function in a variety of species. The purpose of this study was to determine effects of triclosan on pubertal development and thyroid hormone concentrations in the male rat. Weanling rats were exposed to 0, 3, 30, 100, 200, or 300 mg/kg of triclosan by oral gavage from postnatal day (PND) 23 to 53. Preputial separation (PPS) was examined beginning on PND 33. Rats were killed on PND 53, organ weights were recorded and serum was collected for subsequent analysis. Triclosan did not affect growth or the onset of PPS. Serum testosterone was significantly decreased at 200 mg/kg, however no effects were observed on androgen-dependent reproductive tissue weights. Triclosan significantly decreased total serum thyroxine (T4) in a dose-dependent manner at 30 mg/kg and higher (no observed effect level of 3 mg/kg). Triiodothyronine (T3) was significantly decreased only at 200 mg/kg, but thyroid stimulating hormone was not statistically different at any dose. Liver weights were significantly increased at 100 mg/kg triclosan and above suggesting that the induction of hepatic enzymes may have contributed to the altered T4 and T3 concentrations, but it does not appear to correlate with the T4 dose-response. This study demonstrates that triclosan exposure does not alter androgen-dependent tissue weights or onset of PPS; however, triclosan exposure significantly impacts thyroid hormone concentrations in the male juvenile rat.
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Cites
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Triclosan targets lipid synthesis
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Cited by
Triclosan: environmental exposure, toxicity and mechanisms of action
Dann, A. B., & Hontela, A. (2011) · Journal of Applied Toxicology · doi:10.1002/jat.1660 · Cited by 868
Liao, C., & Kannan, K. (2014) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-014-0016-8 · Cited by 344
Personal care products and endocrine disruption: A critical review of the literature
Witorsch, R. J., & Thomas, J. A. (2010) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.515563 · Cited by 334
Triclosan: A Widespread Environmental Toxicant with Many Biological Effects
Yueh, M.-F., & Tukey, R. H. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103417 · Cited by 320
Larsson, K., Ljung Björklund, K., Palm, B., Wennberg, M., Kaj, L., Lindh, C. H., Jönsson, B. A. G., & Berglund, M. (2014) · Environment International · doi:10.1016/j.envint.2014.08.014 · Cited by 304
Metadata
- Authors
- Zorrilla, L. M., Gibson, E. K., Jeffay, S. C., Crofton, K. M., Setzer, W. R., Cooper, R. L., & Stoker, T. E.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-21
- Volume
- 107
- Issue
- 1
- Pages
- 56-64
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2024598483
- Cited by
- 273
- References
- 41
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zorrilla, L. M., Gibson, E. K., Jeffay, S. C., Crofton, K. M., Setzer, W. R., Cooper, R. L., & Stoker, T. E. (2009). The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfn225
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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