Inhibition of PI3k Class III–Dependent Autophagy Prevents Apoptosis and Necrosis by Oxidative Stress in Dopaminergic Neuroblastoma Cells

Castino, Roberta; Bellio, Natascia; Follo, Carlo; Murphy, David; Isidoro, Ciro

doi:10.1093/toxsci/kfq170

Inhibition of PI3k Class III–Dependent Autophagy Prevents Apoptosis and Necrosis by Oxidative Stress in Dopaminergic Neuroblastoma Cells

Hydrogen peroxide (H(2)O(2)) is an extremely reactive oxidoradical that is normally produced as a by-product of the mitochondrial activity and also under several metabolic stress conditions. Autophagy, a lysosomal degradation pathway, is triggered by oxidative stress as a defensive response. How …