The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mitochondria as a Target of Environmental Toxicants
Open accessAbstract
Enormous strides have recently been made in our understanding of the biology and pathobiology of mitochondria. Many diseases have been identified as caused by mitochondrial dysfunction, and many pharmaceuticals have been identified as previously unrecognized mitochondrial toxicants. A much smaller but growing literature indicates that mitochondria are also targeted by environmental pollutants. We briefly review the importance of mitochondrial function and maintenance for health based on the genetics of mitochondrial diseases and the toxicities resulting from pharmaceutical exposure. We then discuss how the principles of mitochondrial vulnerability illustrated by those fields might apply to environmental contaminants, with particular attention to factors that may modulate vulnerability including genetic differences, epigenetic interactions, tissue characteristics, and developmental stage. Finally, we review the literature related to environmental mitochondrial toxicants, with a particular focus on those toxicants that target mitochondrial DNA. We conclude that the fields of environmental toxicology and environmental health should focus more strongly on mitochondria.
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Cites
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Cited by
Heavy metals: toxicity and human health effects
Jomova, K., Alomar, S. Y., Nepovimova, E., Kuca, K., & Valko, M. (2025) · Archives of Toxicology · doi:10.1007/s00204-024-03903-2 · Cited by 983
Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S. S., & Doetsch, P. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081162 · Cited by 777
Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner, V., Picard, M., & Hajnóczky, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0133-0 · Cited by 622
Mitochondrial fusion, fission, and mitochondrial toxicity
Meyer, J. N., Leuthner, T. C., & Luz, A. L. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.019 · Cited by 522
Self-citationPitt, J. A., Trevisan, R., Massarsky, A., Kozal, J. S., Levin, E. D., & Di Giulio, R. T. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.186 · Cited by 413
Metadata
- Authors
- Meyer, J. N., Leung, M. C. K., Rooney, J. P., Sendoel, A., Hengartner, M. O., Kisby, G. E., & Bess, A. S.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-29
- Volume
- 134
- Issue
- 1
- Pages
- 1-17
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2103562463
- Cited by
- 562
- References
- 27
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Meyer, J. N., Leung, M. C. K., Rooney, J. P., Sendoel, A., Hengartner, M. O., Kisby, G. E., & Bess, A. S. (2013). Mitochondria as a Target of Environmental Toxicants. Toxicological Sciences. https://doi.org/10.1093/toxsci/kft102
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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