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Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse1
Abstract
Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 and Catsper2 that have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice. Here we report that Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions. Our data demonstrate that both CATSPER3 and CATSPER4 are required for hyperactivated sperm motility during capacitation and for male fertility. The present study also demands a revisit to the idiopathic male infertility patients who show normal sperm counts and normal initial motility for defects in sperm hyperactivated motility and for potential CATSPER gene mutations. The CATSPER channel also may be an excellent drug target for male contraceptives.
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Citations
Cited by
The biology of infertility: research advances and clinical challenges
Matzuk, M. M., & Lamb, D. J. (2008) · Nature Medicine · doi:10.1038/nm.f.1895 · Cited by 951
Control of hyperactivation in sperm
Suarez, S. S. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn029 · Cited by 584
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Darszon, A., Nishigaki, T., Beltran, C., & Treviño, C. L. (2011) · Physiological Reviews · doi:10.1152/physrev.00028.2010 · Cited by 364
Characterization of genomic regions escaping epigenetic reprogramming in sheep
Braz, C. U., Passamonti, M. M., & Khatib, H. (2024) · Environmental Epigenetics · doi:10.1093/eep/dvad010 · Cited by 19
Metadata
- Authors
- Jin, J., Jin, N., Zheng, H., Ro, S., Tafolla, D., Sanders, K. M., & Yan, W.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-07-01
- Volume
- 77
- Issue
- 1
- Pages
- 37-44
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2004171639
- Cited by
- 187
- References
- 0
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse1. https://app.cochat.ai/papers/10.1095/biolreprod.107.060186
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- Jin, J., Jin, N., Zheng, H., Ro, S., Tafolla, D., Sanders, K. M., & Yan, W. (2007). Catsper3 and Catsper4 Are Essential for Sperm Hyperactivated Motility and Male Fertility in the Mouse1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.107.060186
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