The Ovarian Reserve of Primordial Follicles and the Dynamic Reserve of Antral Growing Follicles: What Is the Link?1
Abstract
The growing follicles develop from a reserve of primordial follicles constituted early in life. From this pre-established reserve, a second ovarian reserve is formed, which consists of gonadotropin-responsive small antral growing follicles and is a dynamic reserve for ovulation. Its size, evaluated by direct antral follicular count or endocrine markers, determines the success of assisted reproductive technologies in humans and embryo production biotechnologies in animals. Strong evidence indicates that these two reserves are functionally related. The size of both reserves appears to be highly variable between individuals of similar age, but the equilibrium size of the dynamic reserve in adults seems to be specific to each individual. The dynamics of both follicular reserves appears to result from the fine tuning of regulations involving two main pathways, the phosphatase and tensin homolog (PTEN)/phosphatidylinositol-3 kinase (PI3K)/3-phosphoinositide-dependent protein kinase-1 (PDPK1)/v-akt murine thymoma viral oncogene homolog 1 (AKT1) and the bone morphogenetic protein (BMP)/anti-Müllerian hormone (AMH)/SMAD signaling pathways. Mutations in genes encoding the ligands, receptors, or signaling effectors of these pathways can accelerate or modulate the exhaustion rate of the ovarian reserves, causing premature ovarian insufficiency (POI) or increase in reproductive longevity, respectively. With female aging, the decline in primordial follicle numbers parallels the decrease in…
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Women with PCOS demonstrate a slower transition from the primordial reserve to the dynamic reserve, with stalled development at the antral stage.
“Women with PCOS thus demonstrate a slower transition from the primordial reserve to the dynamic reserve, with stalled development at the antral stage (Monniaux et al., 2014).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Monniaux et al., 2014
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How Is the Number of Primordial Follicles in the Ovarian Reserve Established?1
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“Women with PCOS thus demonstrate a slower transition from the primordial reserve to the dynamic reserve, with stalled development at the antral stage (Monniaux et al., 2014).”
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Fushimi, Y., Takagi, M., Monniaux, D., Uno, S., Kokushi, E., Shinya, U., Kawashima, C., Otoi, T., Deguchi, E., & Fink-Gremmels, J. (2015) · Reproduction in domestic animals = Zuchthygiene · doi:10.1111/rda.12599 · Cited by 18
“Currently, AMH is considered to be the best endocrine marker of the population of small antral gonadotropinresponsive follicles in cows (Rico et al. 2009; Ireland et al. 2011; Monniaux et al. 2014).”
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“reserve and fertility has long been discussed [2, 27], but few experiments have been able to test this hypothesis.”
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Clément, F., Crépieux, P., Yvinec, R., & Monniaux, D. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110877 · Cited by 16 · see citing works
Self-citationGarcía-Guerra, A., Motta, J., Melo, L. F., Kirkpatrick, B., & Wiltbank, M. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.05.026 · Cited by 16
“This reserve can be further divided into 91 the pre-established reserve, formed by primordial f ollicles, and the dynamic reserve of small 92 antral follicles with a transitional group of folli c es in between primordial and antral follicles, 93 formed by primary and secondary follicles [18].”
BackgroundMSCs–derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis
Elsherbiny, N., Abdel-Maksoud, M. S., Prabahar, K., Mohammedsaleh, Z. M., Badr, O. A. M., Dessouky, A. A., Salem, H. A., Refadah, O. A., Farid, A., Shamaa, A. A., et al. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01545-7 · Cited by 15 · see citing works
The requirement of ubiquitin C-terminal hydrolase L1 in mouse ovarian development and fertility
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Okawa, H., Monniaux, D., Mizokami, C., Fujikura, A., Takano, T., Sato, S., Shinya, U., Kawashima, C., Yamato, O., Fushimi, Y., et al. (2021) · Animals · doi:10.3390/ani11051241 · Cited by 15 · see citing works
“Previous studies have shown that blood AMH concentration in cattle is characteristic of individual cows, and is a reliable endocrine marker for the size of the dynamic reserve of small antral follicles [48], and of the number of ovulation events and embryos produced in response to superovulation or OPU-IVP [13–15,34,3…”
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“Among the potential regulatory mechanisms, a critical role of the PI3K/Akt/mTOR signaling pathway has been proposed (Monniaux et al., 2014; Hsueh et al., 2015; NovellaMaestre et al., 2015; Goldman et al., 2017; Grosbois and Demeestere, 2018; Zhang et al., 2019).”
BackgroundFlutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries
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Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation.
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Gonad differentiation toward ovary.
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In Vitro Production of (Farm) Animal Embryos
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Incessant ovulation: a review of its importance in predicting cancer risk
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A Single-Cell Omics Network Model of Cell Crosstalk during the Formation of Primordial Follicles
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Guo, T.-Y., Huang, L., Yao, W., Du, X., Li, Q.-Q., Ma, M.-L., Li, Q.-F., Liu, H.-L., Zhang, J.-B., & Pan, Z. (2019) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2019.106401 · Cited by 13 · see citing works
- Authors
- Monniaux, D., Clément, F., Dalbiès-Tran, R., Estienne, A., Fabre, S., Mansanet, C., & Monget, P.
- Affiliations
- Université de Tours (FR)
- Institut national de recherche en sciences et technologies du numérique (FR)
- Corresponding author
- Monniaux, Danielle
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-01
- Volume
- 90
- Issue
- 4
- Pages
- 85-85
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2146142669
- Cited by
- 233
- References
- 0
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 15 · 2023: 19 · 2022: 24 · 2021: 24 · 2020: 27 · 2019: 24 · 2018: 27 · 2017: 14 · 2016: 15 · 2015: 15 · 2014: 4
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- ovarian reserve, primordial follicles, antral follicles, dynamic reserves, PTEN/PI3K/AKT signaling, premature ovarian insufficiency, female aging, oocyte quality, assisted reproduction
- MeSH terms
- Aging, Animals, Female, Ovarian Follicle, Humans, Oocytes, Reproductive Techniques, Assisted, Anti-Mullerian Hormone
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