Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis
Open accessAbstract
The reproductive neuroendocrine axis, or hypothalamo-pituitary-gonadal (HPG) axis, is a paragon of complex biological system involving numerous cell types, spread over several anatomical levels communicating through entangled endocrine feedback loops. The HPG axis exhibits remarkable dynamic behaviors on multiple time and space scales, which are an inexhaustible source of studies for mathematical and computational biology. In this review, we will describe a variety of modeling approaches of the HPG axis from a cellular endocrinology viewpoint. We will in particular investigate the questions raised by some of the most striking features of the HPG axis: (i) the pulsatile secretion of hypothalamic and pituitary hormones, and its counterpart, the cell signaling induced by frequency-encoded hormonal signals, and (ii) the dual, gametogenic and glandular function of the gonads, which relies on the tight control of the somatic cell populations ensuring the proper maturation and timely release of the germ cells.
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Self-citationClément, F., Robin, F., & Yvinec, R. (2019) · SIAM Journal on Applied Mathematics · doi:10.1137/17m1161336 · Cited by 8 · see citing works
Self-citationOptimal Control of Cell Mass and Maturity in a Model of Follicular Ovulation
Clément, F., Coron, J., & Shang, P. (2013) · SIAM Journal on Control and Optimization · doi:10.1137/120862247 · Cited by 6 · see citing works
Self-citationThe Follicle-Stimulating Hormone Signaling Network in Gonadal Cells
Clément, F., Yvinec, R., Gallay, N., Gagniac, L., Guillou, F., & Crépieux, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00020-x · Cited by 6 · see citing works
Self-citationAdvances in computational modeling approaches of pituitary gonadotropin signaling
Yvinec, R., Crépieux, P., Reiter, É., Anne Poupon, B., & Clément, F. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1501025 · Cited by 5 · see citing works
Self-citationThe Follicle-Stimulating Hormone Signaling Network in Sertoli Cells
Gallay, N., Gagniac, L., Guillou, F., & Crépieux, P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408134-5.00006-8 · Cited by 4 · see citing works
Self-citationErsöz, E. K., Vidal, A. C., & Clément, F. (2018) · SIAM Journal on Applied Dynamical Systems · doi:10.1137/16m1103695 · Cited by 3 · see citing works
Self-citation
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Dynamic Hormone Control of Stress and Fertility
Zavala, E., Voliotis, M., Zerenner, T., Tabak, J., Walker, J. J., Li, X. F., Terry, J. R., Lightman, S. L., O'Byrne, K., & Tsaneva-Atanasova, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.598845 · Cited by 34 · see citing works
- Authors
- Clément, F., Crépieux, P., Yvinec, R., & Monniaux, D.
- Affiliations
- Centre Inria de Saclay (FR)
- Université de Tours (FR)
- Corresponding author
- Clément, Frédérique
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 518
- Pages
- 110877
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W3036528433
- Cited by
- 16
- References
- 111
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 1 · 2020: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular and Cellular Endocrinology (acceptedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Funders
- INRAE
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- hypothalamic-pituitary-gonadal axis, cellular endocrinology, mathematical modeling, pulsatile hormone secretion, signal transduction, gonad development, germ cell maturation
- MeSH terms
- Animals, Endocrinology, Female, Gonads, Humans, Hypothalamo-Hypophyseal System, Male, Models, Theoretical, Pituitary-Adrenal System, Reproduction, Signal Transduction, Endocrine Cells
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