The DOI matches its Crossref record.
Establishment and Characterization of Two Distinct Mouse Testicular Epithelial Cell Line
Abstract
Two cell lines have been isolated from testis of immature BALB/c mice. These lines have each been cloned several times and have been established in culture for over 2 years. The cells are epithelial in appearance and do not form tumors when injected into BALB/c − nu/nu mice. The cell lines can be said to be two distinct cell types on the basis of their morphology, hormone response, responses to gonadotropins, and metabolism of steroids. One line (TM4) has been tentatively identified as being of Sertoli cell origin, since it shows a growth response to purified ovFSH and an increase in cAMP in the presence of FSH but not LH. The other line (TM3), believed to be Leydig cells, is not growth-stimulated by either LH or FSH, shows an increase in cAMP in the presence of LH, and a change in the metabolism of [14C]-cholesterol in the presence of LH.
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Citations
Cited by
Expression and Regulation of the Proenkephalin Gene in Rat Sertoli Cells
Kew, D., & Kilpatrick, D. L. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-1-179 · Cited by 36
Metadata
- Authors
- Matfier, J. P.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-08-01
- Volume
- 23
- Issue
- 1
- Pages
- 243-252
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2092941848
- Cited by
- 396
- References
- 0
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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