The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Expression and Regulation of the Proenkephalin Gene in Rat Sertoli Cells
Open accessAbstract
Previous studies have shown that multiple forms of proenkephalin RNA are present in the rat and mouse testis that are cell type specific: a 1700-nucleotide transcript, unique to the testis, found in spermatogenic cells, and a 1450-nucleotide form of somatic cell origin. In the present studies, rat Sertoli cells are shown to contain the 1450-nucleotide form of proenkephalin RNA. The concentration of this transcript is quite low immediately after Sertoli cell isolation, but increases after 1 day in culture to a constant level. Proenkephalin RNA levels are stimulated severalfold by FSH and cAMP, but are not significantly affected by LH or testosterone. These studies demonstrate that Sertoli cells are at least one source of the somatic, 1450-nucleotide form of proenkephalin RNA in the rat testis. The expression of opioid peptide genes by Sertoli cells as well as by germ and Leydig cells is further evidence for the postulated autocrine or paracrine functions of these peptides in the testis.
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“In any case, the long-term persistence of (re-)activatable autoantigen-specific ThEx cells in patients in remission may well explain the less-than-perfect treatment efficacy of steroid-sparing agents, 64-67 depletion of CD19/CD20 memory B cells, 68,69 as well as exacerbation of disease by b -IFN. 27,70”
From Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases (2024) · cites this paper as [64]
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Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725
Spermatogenic cells of the prepuberal mouse: isolation and morphological characterization
Bellve, A., Cavicchia, J. C., Millette, C. F., O'Brien, D. A., Bhatnagar, Y. M., & Dym, M. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.68 · Cited by 1,386
Regulation of the Seminiferous Epithelium*
PARVINEN, M. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-4-404 · Cited by 631
Pure Sertoli Cell Cultures: A New Model for the Study of Somatic—Germ Cell Interactions
Galdieri, M., Elio Ziparo, A., Palombi, F., Russo, M. A., & Stefanini, M. (1981) · Journal of Andrology · doi:10.1002/j.1939-4640.1981.tb00625.x · Cited by 409
Establishment and Characterization of Two Distinct Mouse Testicular Epithelial Cell Line
Matfier, J. P. (1980) · Biology of Reproduction · doi:10.1095/biolreprod23.1.243 · Cited by 396
Biochemistry of the enkephalins and enkephalin-containing peptides
Udenfriend, S., & Kilpatrick, D. L. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90149-2 · Cited by 271
Self-citationSkinner, M. K., & Fritz, I. B. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.114 · Cited by 267
REGULATION OF THE TESTIS SERTOLI CELL BY FOLLICLE STIMULATING HORMONE
Means, A. R., Dedman, J. R., Tash, J. S., Tindall, D. J., SICKLE, M. V., & Welsh, M. J. (1980) · Annual Review of Physiology · doi:10.1146/annurev.ph.42.030180.000423 · Cited by 231
Howells, R., Kilpatrick, D. L., Bhatt, R. R., Monahan, J. J., Poonian, M. S., & Udenfriend, S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.23.7651 · Cited by 188
Self-citationCharacterization and Localization of Proopiomelanocortin Messenger RNA in the Adult Rat Testis
Pintar, J. E., Schachter, B. S., Herman, A. B., Durgerian, S., & Krieger, D. T. (1984) · Science · doi:10.1126/science.6740329 · Cited by 183
Research works printed but not linked: 1
- Kierzenbaum AL, Tres LL 1981 Structure and function of Sertoli cells in culture. In: Jagiello G, Vogel HJ (eds) Bioregulators of Reproduction. Academic Press, NY, pp 207-228
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Gnessi, L., Fabbri, A., & Spera, G. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0310 · Cited by 306
“cells isolated from 20-day-old rats (281, 282).”
BackgroundKilpatrick, D. L., Zinn, S. A., Fitzgerald, M., Higuchi, H., Sabol, S. L., & Meyerhardt, J. A. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3717 · Cited by 108
Self-citationSaggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.-S., Dargvainiene, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.005 · Cited by 79
Stage-Specific Regulation of Stem Cell Factor Gene Expression in the Rat Seminiferous Epithelium
Yan, W., Linderborg, J., Suominen, J., & Toppari, J. (1999) · Endocrinology · doi:10.1210/en.140.3.1499 · Cited by 74
Regulation of Male Fertility by the Opioid System
Subirán, N., Casis, L., & Irazusta, J. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00268 · Cited by 67
Metadata
- Authors
- Kew, D., & Kilpatrick, D. L.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1989-01
- Volume
- 3
- Issue
- 1
- Pages
- 179-184
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2048538190
- Cited by
- 36
- References
- 38
- Citations by year
- 2024: 1 · 2015: 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Andrew W. Mellon Foundation
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-36468)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- proenkephalin, Sertoli cells, testis, opioid peptides, gene expression regulation, follicle-stimulating hormone, cyclic AMP, luteinizing hormone, testosterone, autocrine and paracrine signaling
- MeSH terms
- Animals, Cells, Cultured, Enkephalins, Colforsin, Follicle Stimulating Hormone, Gene Expression Regulation, Male, Protein Precursors, RNA, Sertoli Cells, Dihydrotestosterone, Testosterone, Time Factors, 1-Methyl-3-isobutylxanthine, 8-Bromo Cyclic Adenosine Monophosphate, Rats
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- CoChat. (2026). Citation check: Expression and Regulation of the Proenkephalin Gene in Rat Sertoli Cells. https://app.cochat.ai/papers/10.1210/mend-3-1-179
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- Kew, D., & Kilpatrick, D. L. (1989). Expression and Regulation of the Proenkephalin Gene in Rat Sertoli Cells. Molecular Endocrinology. https://doi.org/10.1210/mend-3-1-179
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
