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Differential Effects of the Perinatal Steroid Environment on Three Sexually Dimorphic Parameters of the Rat Brain1
Abstract
Gonadectomy of male rats was performed at 0, 6-7 (6h), 12-13 (12h), or 24 h postnatally in order to examine the influence of testosterone exposure on sexual differentiation of the brain. The indices examined were: the volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) and luteinizing hormone (LH) and follicle-stimulating hormone (FSH) titers following estradiol benzoate (EB) and progesterone (P) administration. Control animals were sham-operated at 0 h and gonadectomized at 29 days of age (sham). A decrease in the percentage of males with elevated plasma LH levels following P was found with increasing delay before gonadectomy. Significant (P less than 0.001) differences existed in the amplitude of plasma LH titers 5 h following P administration between sham, 0 h, and 6 h groups. Follicle-stimulating hormone was also elevated in all neonatally gonadectomized male groups following P administration, but there was no difference between the groups. Volume of the SDN-POA was significantly (P less than 0.001) smaller in all gonadectomized males when compared to that of sham-operated males, but no differences existed between males gonadectomized at the different hours postpartum. In female rats gonadectomized at 0 h (F0h), LH levels were elevated 5 h following P, but only to a magnitude of 36% of that of sham-operated controls (P less than 0.001). Volume of the SDN-POA of the F0h group was significantly reduced (P less than 0.05) when compared to that of sham fem…
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Neonatal castration of male rats enables them to respond to estradiol in adulthood with an LH surge.
“Evidence that positive feedback is sexually differentiated by the neonatal actions of testosterone comes from studies showing that neonatal castration of male rats allows them to respond to estradiol in adulthood with an LH surge (Handa, Corbier, Shryne, Schoonmaker, & Gorski, 1985).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Handa, Corbier, Shryne, Schoonmaker, & Gorski, 1985
Estrogen or testosterone treatment of neonatal females defeminizes the brain so that they no longer produce an LH surge in response to estradiol in adulthood.
“Conversely, estrogen or testosterone treatment of neonatal females defeminizes the brain such that they can no longer respond to estradiol in adulthood with a surge of LH (Handa, Corbier, Shryne, Schoonmaker, & Gorski, 1985).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Handa, Corbier, Shryne, Schoonmaker, & Gorski, 1985
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Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710
Self-citationGnRH signaling, the gonadotrope and endocrine control of fertility
Bliss, S. P., Navratil, A. M., Xie, J., & Roberson, M. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.002 · Cited by 259
Foecking, E. M., Szabo, M., Schwartz, N. B., & Levine, J. E. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.039800 · Cited by 165
Metadata
- Authors
- Handa, R. J., Corbier, P., Shryne, J. E., Schoonmaker, J. N., & Gorski, R. A.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Handa, R. J.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-05-01
- Volume
- 32
- Issue
- 4
- Pages
- 855-864
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2165820694
- Cited by
- 73
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-01182)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- gonadectomy, sexual differentiation of the brain, sexually dimorphic nucleus, preoptic area, luteinizing hormone, follicle-stimulating hormone, estradiol benzoate, progesterone, androgen exposure, masculinization, brain development, sex differences
- MeSH terms
- Animals, Animals, Newborn, Brain, Castration, Estradiol, Feedback, Female, Follicle Stimulating Hormone, Luteinizing Hormone, Male, Preoptic Area, Progesterone, Sex Differentiation, Testosterone, Rats
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