The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
GnRH Effects on Placental Hormones during Gestation. lll. Prostaglandin E, Prostaglandin F, and 13,14-d ihydro- 15-keto-Prostaglandin F1
Abstract
We studied the release of prostaglandin E (PGE), prostaglandin F (PGF) and 13,14-dihydro-15-keto-prostaglandin F (MPF) from explants of human placentas of different gestational ages and the effect of gonadotropin-releasing hormone (GnRH) on this release. The greatest basal release of PGE, PGF and MPF was in the cultures from 9- to 13-wk placentas, with the release on the second and third days of culture increasing 4- to 10-fold from that of the first day. In cultures from 15-wk to term placentas, the initial basal release (Day 1) of these prostaglandins was only slightly higher than in cultures from 6-wk placentas. In cultures from term placentas, the later increase with extended culture was absent or very small. Addition of synthetic GnRH to the cultures from 6- to 9-wk placentas effected no significant change in release of PGE, PGF or MPF. However, GnRH added to the cultures from 13-wk placentas effected a dose-related inhibition of these prostaglandins. After 15 wk, we observed a stimulation of these prostaglandins by GnRH that was as much as 50-fold; stimulation was highly significant in the cultures from 16- and 17-wk, as well as in those from the term placentas. These data demonstrate an action of GnRH on prostaglandin release and indicate that both the basal release of PGE, PGF and MPF and the response to GnRH are related to the gestational age of the placenta.
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“The loss of ERK signaling in GnRHR-expressing cells within the maternal-fetal interface may blunt or abrogate the release of PGF2α thus contributing to the delay in onset of parturition61.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [61]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Human placental receptors for luteinizing hormone releasing hormone
Currie, A., Fraser, H. M., & Sharpe, R. M. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91749-6 · Cited by 138
Prostaglandin Output in Relation to Parturition by Cells Dispersed from Human Intrauterine Tissues*
Olson, D. M., Skinner, K. A., & Challis, J. R. G. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-4-694 · Cited by 134
Content of luteinizing hormone-releasing factor in the human placenta
Siler-Khodr, T. M., & Khodr, G. S. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90369-1 · Cited by 123
Self-citationBélisle, S., Guévin, J.-F., Bellabarba, D., et al. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-1-119 · Cited by 110
Siler-Khodr, T. M., Khodr, G. S., Valenzuela, G., et al. (1986) · Biology of Reproduction · doi:10.1095/biolreprod34.2.255 · Cited by 48
Self-citationExtrahypothalamic Luteinizing Hormone-Releasing Factor (LRF): Release of Immunoreactive LRF in Vitro
Siler-Khodr, T. M., & Khodr, G. S. (1979) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44236-6 · Cited by 47
Self-citationChanges in luteinizing hormone-releasing hormone in human placenta throughout pregnancy.
Miyake, A., Sakumoto, T., Aono, T., et al. (1982) · PubMed · Cited by 35
Prostaglandin production by human term placentas in vitro
HARPER, M. J. K., Khodr, G. S., & Valenzuela, G. (1983) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(83)90116-6 · Cited by 26
Self-citationHaning, R. V., Choi, L., Kiggens, A. J., et al. (1982) · Prostaglandins · doi:10.1016/0090-6980(82)90007-7 · Cited by 22
Haning, R. V., Choi, L., Kiggens, A. J., et al. (1982) · Prostaglandins · doi:10.1016/0090-6980(82)90019-3 · Cited by 11
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Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13
Metadata
- Authors
- Siler-Khodr, T. M., Khodr, G. S., Valenzuela, G., Harper, M. J. K., & Rhode, J.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Siler-Khodr, T. M.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-09-01
- Volume
- 35
- Issue
- 2
- Pages
- 312-319
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2117743301
- Cited by
- 25
- References
- 11
- Citations by year
- 2023: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 14852, HD 10202)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Keywords
- gonadotropin-releasing hormone, prostaglandin E, prostaglandin F, gestational age, human placenta, placental explant culture
- MeSH terms
- Female, Gestational Age, Humans, Pituitary Hormone-Releasing Hormones, Placenta, Pregnancy, Prostaglandins, Prostaglandins E, Prostaglandins F, Dinoprost, In Vitro Techniques
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