Maternal Melatonin Treatment Influences Rates of Neonatal Development of Meadow Vole Pups1
Abstract
Meadow vole dams, housed in a 14L:10D photoperiod were injected daily 3 h before onset of darkness with 10 micrograms melatonin. Treatment during gestation or lactation produced offspring that exhibited altered somatic, testicular, and pelage growth. Gestational melatonin treatment decreased preweaning weight gain, delayed testicular development, and increased pelage growth in offspring, whereas melatonin treatment during lactation increased pelage depth at weaning and increased post-weaning somatic growth. These results suggest that pre- and postnatal maternal melatonin secretory patterns influence postnatal development of photosensitive traits in offspring.
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The failure of stable maternal rhythms to rescue offspring outcomes is in contrast with ELS and maternal melatonin literature, in which neonatal interventions rescue circadian- and ELS-induced effects in offspring.
“The failure of stable maternal rhythms to rescue offspring outcomes are in contrast with both the ELS and maternal melatonin literature, in which neonatal interventions rescue circadian-22, 53–55 and ELS-induced effects in offspring56.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [53]
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Further reading and references
(2004) · Cambridge University Press eBooks · doi:10.1017/cbo9781139106955.012
- Authors
- Lee, T. M., Spears, N., Tuthill, C. R., & Zucker, I.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Lee, Theresa M.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-03-01
- Volume
- 40
- Issue
- 3
- Pages
- 495-502
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2014176926
- Cited by
- 58
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24575, HD-02982)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- melatonin, maternal treatment, Microtus pennsylvanicus, postnatal development, gestation, lactation, testicular development, physical growth, photoperiod, offspring development
- MeSH terms
- Animals, Birth Weight, Energy Intake, Arvicolinae, Female, Hair, Lactation, Male, Melatonin, Periodicity, Pregnancy, Pregnancy, Animal, Prenatal Exposure Delayed Effects, Reproduction, Testis, Uterus
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