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Expression of Vascular Endothelial Growth Factor and Placenta Growth Factor in Human Placenta1
Open accessAbstract
Normal development and function of the placenta requires invasion of the maternal decidua by trophoblasts, followed by abundant and organized vascular growth. Little is known of the significance and function of the vascular endothelial growth factor (VEGF) family, which includes VEGF, VEGF-B, and VEGF-C, and of placenta growth factor (PIGF) in these processes. In this study we have analyzed the expression of VEGF and PIGF mRNAs and their protein products in placental tissue obtained from noncomplicated pregnancies. Expression of VEGF and PIGF mRNA was observed by in situ hybridization in the chorionic mesenchyme and villous trophoblasts, respectively. Immunostaining localized the VEGF and PIGF proteins in the vascular endothelium, which was defined by staining for von Willebrand factor and for the Tie receptor tyrosine kinase, an early endothelial cell marker. VEGF-B and VEGF-C mRNAs were strongly expressed in human placenta as evidenced by Northern blot analysis. These data imply that VEGF and PIGF are produced by different cells but that both target the endothelial cells of normal human term placenta.
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Citations
Cited by
The discovery of placenta growth factor and its biological activity
De Falco, S. (2012) · Experimental and Molecular Medicine · doi:10.3858/emm.2012.44.1.025 · Cited by 425
Iwawaki, T., Akai, R., Yamanaka, S., & Kohno, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903775106 · Cited by 377
Chaiworapongsa, T., Romero, R., Kim, Y. M., Kim, G. J., Kim, M. R., Espinoza, J., Bujold, E., Gonçalves, L., Gomez, R., Edwin, S., et al. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050400028816 · Cited by 359
Vuorela, P., Andersson, S., Carpén, O., Ylikorkala, O., & Halmesmäki, E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1196 · Cited by 50
Self-citationThe characterization of fibrocyte-like cells: A novel fibroblastic cell of the placenta
Riddell, M. R., Winkler-Lowen, B., Chakrabarti, S., Dunk, C., Davidge, S. T., & Guilbert, L. J. (2012) · Placenta · doi:10.1016/j.placenta.2011.12.012 · Cited by 14
Metadata
- Authors
- Vuorela, P., Hatva, E., Lymboussaki, A., Kaipainen, A., Joukov, V., Persico, M. G., Alitalo, K., & Halmesmäki, E.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-02-01
- Volume
- 56
- Issue
- 2
- Pages
- 489-494
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2037730388
- Cited by
- 260
- References
- 0
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vuorela, P., Hatva, E., Lymboussaki, A., Kaipainen, A., Joukov, V., Persico, M. G., Alitalo, K., & Halmesmäki, E. (1997). Expression of Vascular Endothelial Growth Factor and Placenta Growth Factor in Human Placenta1. Biology of Reproduction. https://doi.org/10.1095/biolreprod56.2.489
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
