Role of gonadotropin-releasing hormone pulse frequency in differential regulation of gonadotropins in the gilt

Lüking Jayes, Friederike C.; Britt, Jack H.; Esbenshade, Kenneth L.

doi:10.1095/biolreprod56.4.1012

Cited by 30Hypothalamic control of reproductive hormonesReproductive Physiology in LivestockGrowth Hormone and Insulin-like Growth Factors

Role of gonadotropin-releasing hormone pulse frequency in differential regulation of gonadotropins in the gilt

Lüking Jayes, Friederike C., Britt, Jack H., Esbenshade, Kenneth L.·1997·Biology of Reproduction

DOI 10.1095/biolreprod56.4.1012

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Abstract

We tested the hypothesis that different GnRH pulse frequencies will affect serum LH and FSH differently. Ovariectomized gilts (n = 6), immunized against GnRH, were given 200-ng pulses of GnRH agonist (GnRH-A) every 180 min for 3 days (pretreatment), followed by GnRH-A pulses every 30, 60, or 180 min for 3 days (treatment) in a Latin rectangle design. Mean gonadotropin concentrations did not change over time when GnRH pulses were administered every 180 min. Initiation of high GnRH-A pulse frequency (30 min) caused a robust increase in serum LH to 265% of the pretreatment level (p < or = 0.007) and a more moderate increase in serum FSH to 127% of pretreatment level (p < or = 0.02). After 66 h of frequent pulsing, desensitization had occurred and serum LH concentrations were similar to pretreatment concentrations, but serum FSH had decreased to 53% of pretreatment levels (p < or = 0.0008). After 72 h of treatment, 5 micrograms GnRH-A was infused to estimate residual releasable pools of LH and FSH, and the amounts of LH and FSH released were negatively correlated with GnRH-A pulse frequency. The results of this study imply that the LH surge is terminated because the pituitary gland becomes incapable of responding to an otherwise adequate stimulus, and not because of exhaustion of releasable LH pools. Our results confirm that in the pig the response to altered GnRH-A pulse frequency differs between LH and FSH. High GnRH pulse frequency is more effective in acutely releasing LH than FSH. Low pulse frequency of GnRH supports FSH synthesis and release, but is not as effective in increasing LH concentrations, while high GnRH pulse frequency inhibits FSH synthesis and release.

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This occurs via enhanced release of 2 glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the anterior pituitary, promoting steroidogenesis and the maturation of gametes.
“This occurs via enhanced release of 2 glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the anterior pituitary (15), promoting steroidogenesis and the maturation of gametes (16).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [15]

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Authors: Lüking Jayes, F. C., Britt, J. H., & Esbenshade, K. L.
Affiliations: North Carolina State University (US)
Corresponding author: Britt, Jack H.
ORCID: Britt, Jack H.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 1997-04-01
Volume: 56
Issue: 4
Pages: 1012-1019
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod56.4.1012
OpenAlex: W2095807278
Cited by: 30
References: 57
Citations by year: 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 1
FWCI: 0.34
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: gonadotropin-releasing hormone, GnRH pulse frequency, GnRH agonist, luteinizing hormone, follicle-stimulating hormone, swine reproduction
MeSH terms: Activity Cycles, Animals, Antibody Formation, Drug Administration Schedule, Female, Follicle Stimulating Hormone, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Ovariectomy, Radioimmunoassay, Swine

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Role of gonadotropin-releasing hormone pulse frequency in differential regulation of gonadotropins in the gilt

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