The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Angiogenesis in the Placenta1
Abstract
The mammalian placenta is the organ through which respiratory gases, nutrients, and wastes are exchanged between the maternal and fetal systems. Thus, transplacental exchange provides for all the metabolic demands of fetal growth and development. The rate of transplacental exchange depends primarily on the rates of uterine (maternal placental) and umbilical (fetal placental) blood flows. In fact, increased uterine vascular resistance and reduced uterine blood flow can be used as predictors of high risk pregnancies and are associated with fetal growth retardation. The rates of placental blood flow, in turn, are dependent on placental vascularization, and placental angiogenesis is therefore critical for the successful development of viable, healthy offspring. Recent studies, including gene knockouts in mice, indicate that the vascular endothelial growth factors represent a major class of placental angiogenic factors. Other angiogenic factors, such as the fibroblast growth factors or perhaps the angiopoietins, also may play important roles in placental vascularization. In addition, recent observations suggest that these angiogenic factors interact with the local vasodilator nitric oxide to coordinate placental angiogenesis and blood flow. In the future, regulators of angiogenesis that are currently being developed may provide novel and powerful methods to ensure positive outcomes for most pregnancies.
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Citations
Cites
The Physiology of Reproduction
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Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
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The Biology of Vascular Endothelial Growth Factor
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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
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Cited by
Maternal Nutrition and Fetal Development
Bazer, F. W., Spencer, T. E., Wu, G., Cudd, T. A., & Meininger, C. J. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.9.2169 · Cited by 1,019
Aspects of Human Fetoplacental Vasculogenesis and Angiogenesis. II. Changes During Normal Pregnancy
Kaufmann, P., Mayhew, T. M., & Charnock-Jones, D. S. (2004) · Placenta · doi:10.1016/j.placenta.2003.10.009 · Cited by 437
Evidence for altered placental blood flow and vascularity in compromised pregnancies
Reynolds, L. P., Caton, J. S., Redmer, D. A., Grazul‐Bilska, A. T., Vonnahme, K. A., Borowicz, P. P., Luther, J. S., Wallace, J. M., Wu, G., & Spencer, T. E. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.104430 · Cited by 358
Self-citationA field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
Chang, C.-P., Neilson, J. R., Bayle, J. H., Gestwicki, J. E., Kuo, A., Stankunas, K., Graef, I. A., & Crabtree, G. R. (2004) · Cell · doi:10.1016/j.cell.2004.08.010 · Cited by 331
Dietary l-Arginine Supplementation Enhances the Reproductive Performance of Gilts
Mateo, R. D., Wu, G., Bazer, F. W., Park, J. C., Shinzato, I., & Kim, S. W. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.652 · Cited by 324
Metadata
- Authors
- Reynolds, L. P., & Redmer, D. A.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04-01
- Volume
- 64
- Issue
- 4
- Pages
- 1033-1040
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2120294151
- Cited by
- 516
- References
- 91
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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