Evidence for altered placental blood flow and vascularity in compromised pregnancies
Open accessAbstract
The placenta is the organ that transports nutrients, respiratory gases, and wastes between the maternal and fetal systems. Consequently, placental blood flow and vascular development are essential components of normal placental function and are critical to fetal growth and development. Normal fetal growth and development are important to ensure optimum health of offspring throughout their subsequent life course. In numerous sheep models of compromised pregnancy, in which fetal or placental growth, or both, are impaired, utero‐placental blood flows are reduced. In the models that have been evaluated, placental vascular development also is altered. Recent studies found that treatments designed to increase placental blood flow can ‘rescue’ fetal growth that was reduced due to low maternal dietary intake. Placental blood flow and vascular development are thus potential therapeutic targets in compromised pregnancies.
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There are decreases in capillary vascular density and/or volume in the caruncular part of the ovine placentomes, irrespective of whether the mothers were over- or under-nourished during pregnancy.
“In particular, there are decreases in capillary vascular density and/or volume in the caruncular part of the ovine placentomes, irrespective of whether the mothers were over-or under-nourished during pregnancy (454, 463).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [463]
These changes in weight are accompanied by alterations in the gross morphology of the ovine placentomes and in their vascularity.
“These changes in weight are accompanied by alterations in the gross morphology of the ovine placentomes and in their vascularity (454, 463).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [463]
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- Authors
- Reynolds, L. P., Caton, J. S., Redmer, D. A., Grazul‐Bilska, A. T., Vonnahme, K. A., Borowicz, P. P., Luther, J. S., Wallace, J. M., Wu, G., & Spencer, T. E.
- Affiliations
- North Dakota State University (US)
- University of Aberdeen (GB)
- Texas A&M University (US)
- ORCID
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2006-03-28
- Volume
- 572
- Issue
- 1
- Pages
- 51-58
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1779650
- OpenAlex
- W2096204842
- Cited by
- 358
- References
- 87
- Citations by year
- 2026: 16 · 2025: 9 · 2024: 18 · 2023: 19 · 2022: 26 · 2021: 22 · 2020: 25 · 2019: 22 · 2018: 26 · 2017: 23 · 2016: 20 · 2015: 16 · 2014: 19 · 2013: 24 · 2012: 12
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- placental blood flow, placental vascularization, fetal growth restriction, uteroplacental circulation, placental vascular development, sheep model, maternal diet, placental function
- MeSH terms
- Adaptation, Physiological, Animals, Blood Flow Velocity, Clinical Trials as Topic, Female, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy, Pregnancy Complications, Evidence-Based Medicine, Placental Circulation, Fetal Development
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