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Brevetoxins: unique polyether dinoflagellate toxins
Abstract
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems. Their effect is excitatory, mediated by the enhancement of cellular Na + influx. Brevetoxins bind at site 5 on the voltage‐sensitive sodium channel, a specificity shared with ciguatoxin. This site is allosterically linked to other natural toxin binding sites on the channel.—B aden , D. G. Brevetoxins: unique polyether dinoflagellate toxins. FASEB J. 3: 1807‐1817; 1989.
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Cited by
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Singh, S., Kate, B. N., & Banerjee, U. C. (2005) · Critical Reviews in Biotechnology · doi:10.1080/07388550500248498 · Cited by 619
The changing face of ciguatera
Lewis, R. J. (2001) · Toxicon · doi:10.1016/s0041-0101(00)00161-6 · Cited by 332
Kimura, K., Okuda, S., Nakayama, K., Shikata, T., Takahashi, F., Yamaguchi, H., Skamoto, S., Yamaguchi, M., & Tomaru, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0142731 · Cited by 39
Metadata
- Authors
- Baden, D. G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1989-05
- Volume
- 3
- Issue
- 7
- Pages
- 1807-1817
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1735272425
- Cited by
- 316
- References
- 0
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baden, D. G. (1989). Brevetoxins: unique polyether dinoflagellate toxins. The FASEB Journal. https://doi.org/10.1096/fasebj.3.7.2565840
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
