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Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo
Abstract
To determine the role of neutrophils in the pathogenesis of hepatic ischemia/reperfusion injury, livers from male Fischer rats were subjected to 45 min of no‐flow ischemia followed by reperfusion for up to 24 h. Two phases of liver injury were identified, an initial phase during the first hour of reperfusion and a later progression phase with 80 ± 3% hepatocyte necrosis and an 80‐fold increase of neutrophil infiltration in the liver after 24 h. Pretreatment with a monoclonal antibody against neutrophils, which caused consistent neutropenia, protected the liver from reperfusion injury as indicated by 28 ± 10% necrosis, and 84% reduction of hepatic neutrophil accumulation and a complete recovery of the hepatic ATP content. Our data suggest that the later progression phase of reperfusion injury after hepatic no‐flow ischemia is mediated mainly by neutrophils.—J aeschke , H.; F arhood , A.; S mith , C. W. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J. 4: 3355–3359; 1990.
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Citations
Cited by
Immunology in the liver — from homeostasis to disease
Heymann, F., & Tacke, F. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.200 · Cited by 1,180
Jaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 964
Self-citationSterile inflammation in the liver
Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666
More friend than foe: the emerging role of neutrophils in tissue repair
Peiseler, M., & Kubes, P. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124616 · Cited by 423
Reactive oxygen and mechanisms of inflammatory liver injury
Jaeschke, H. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02207.x · Cited by 355
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Metadata
- Authors
- Jaeschke, H., Farhood, A., & Smith, C. W.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1990-12
- Volume
- 4
- Issue
- 15
- Pages
- 3355-3359
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1574945736
- Cited by
- 730
- References
- 0
- FWCI
- 19.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jaeschke, H., Farhood, A., & Smith, C. W. (1990). Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. The FASEB Journal. https://doi.org/10.1096/fasebj.4.15.2253850
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