The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Reactive oxygen and mechanisms of inflammatory liver injury
Open accessAbstract
Reactive oxygen species (ROS) are important cytotoxic and signalling mediators in the pathophysiology of inflammatory liver diseases. They can be generated by resident and infiltrating phagocytes and/or intracellularly in every liver cell type after stimulation with cytokines. Although ROS are able to cause cell destruction by massive lipid peroxidation, in most cases, ROS are more likely to modulate signal transduction pathways by affecting redox‐sensitive enzymes, organelles (e.g. mitochondria) and transcription factors. Thus, ROS can directly induce and/or regulate apoptotic and necrotic cell death. In addition, ROS can have indirect effects on the pathophysiology by supporting protease activity through inactivation of antiproteases and by modulating the formation of inflammatory mediators and adhesion molecules. Many of the effects of ROS may occur simultaneously or sequentially in the pathophysiology. Although mainly described in this review as detrimental, ROS are essential for host‐defence functions of phagocytes and can modulate the formation of mediators involved in regulating sinusoidal blood flow and liver regeneration. Thus, continuous efforts are necessary to improve our understanding of the role of ROS in the pathophysiology of inflammatory liver diseases and to discover therapeutic interventions that selectively target the negative effects of reactive oxygen formation.
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Cites
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Cited by
Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology · doi:10.1002/hep.21093 · Cited by 284
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Self-citationAntioxidants: an integrative approach
Lachance, P. A., Nakat, Z., & Jeong, W.-S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00636-0 · Cited by 140
Pan, C.-W., Pan, Z.-Z., Hu, J.-J., Chen, W.-L., Zhou, G.-Y., Lin, W., Jin, L.-X., & Xu, C.-L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.006 · Cited by 105
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Metadata
- Authors
- Jaeschke, H.
- Venue
- Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2000-07
- Volume
- 15
- Issue
- 7
- Pages
- 718-724
- ISSN
- 0815-9319 (ISSN-L)
- 1440-1746
- OpenAlex
- W2117825601
- Cited by
- 355
- References
- 71
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
