The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes
Abstract
Folate coenzymes supply the activated one‐carbon units required in nucleic acid biosynthesis, mitochondrial and chloroplast protein biosynthesis, amino acid metabolism, methyl group biogenesis, and vitamin metabolism. Because of its central role in purine and thymidylate biosynthesis, folate‐mediated one‐carbon metabolism has been the target of many anticancer drug therapies. This review is a summary of recent results that suggest that folate‐mediated one‐carbon metabolism is highly compartmentalized in eukaryotic cells. Evidence exists for compartmentation of folate coenzymes and their one‐carbon units between intracellular organelles, for substrate channeling of folate coenzymes, and for compartmentation by intracellular folate‐binding proteins. Metabolic, regulatory, and therapeutic implications of these processes are discussed.—Appling, D. R. Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes. FASEB J. 5: 2645‐2651; 1991.
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Cites
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Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells
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Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism
Tibbetts, A. S., & Appling, D. R. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104810 · Cited by 692
Self-citationChapter 1 Folate‐Mediated One‐Carbon Metabolism
Fox, J. T., & Stover, P. J. (2008) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)00401-9 · Cited by 402
Inflammation, vitamin B6 and related pathways
Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.08.001 · Cited by 382
One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies ,
Stover, P. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.113670 · Cited by 276
The role of epigenetics in renal ageing
Shiels, P. G., McGuinness, D., Eriksson, M., Kooman, J. P., & Stenvinkel, P. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.78 · Cited by 114
Metadata
- Authors
- Appling, D. R.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1991-09
- Volume
- 5
- Issue
- 12
- Pages
- 2645-2651
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1788126413
- Cited by
- 349
- References
- 37
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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