The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction 1
Abstract
The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine‐based phospholipid that makes up the outer monolayer of the outer membrane of most gram‐negative bacteria. Because of its profound pharmacological effects on animal cells, especially those of the immune system, lipid A is also known as endotoxin. Despite decades of earlier work, the precise chemistry of endotoxins and the biochemical pathways for their enzymatic synthesis have been elucidated only within the past 5 years. In this review, we summarize the essentials of endotoxin biochemistry and also present recent experiments aimed at identifying surface receptors, signal‐transducing elements, transcriptional factors, and key intracellular targets involved in the response of animal cells to endotoxins.—Raetz, C. R. H.; Ulevitch, R. J.; Wright, S. D.; Sibley, C. H.; Ding, A.; Nathan, C. F. Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5: 2652‐2660; 1991.
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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
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Self-citationLIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis
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Structure and Function of Lipopolysaccharide Binding Protein
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Self-citationNF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
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Self-citationBaeuerle, P. A., & Baltimore, D. (1988) · Cell · doi:10.1016/0092-8674(88)90382-0 · Cited by 1,166
ENDOTOXINS AND DISEASE MECHANISMS
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TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR
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Priming: Getting Ready for Battle
Conrath, U., Beckers, G. J. M., Flors, V., García-Agustín, P., Jakab, G., Mauch, F., Newman, M.-A., Pieterse, C. M. J., Poinssot, B., Pozo, M. J., et al. (2006) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi-19-1062 · Cited by 1,532
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)
Qureshi, S. T., Larivière, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., & Malo, D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.615 · Cited by 1,525
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442
Self-citationToll–Like Receptor 4 Is Involved in the Mechanism of Early Alcohol–Induced Liver Injury in Mice
Uesugi, T., Froh, M., Arteel, G. E., Bradford, B. U., & Thurman, R. G. (2001) · Hepatology · doi:10.1053/jhep.2001.25350 · Cited by 488
Metadata
- Authors
- Raetz, C. R. H., Ulevitch, R. I., Wright, S. D., Sibley, C. H., Ding, A., & Nathan, C. F.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1991-09
- Volume
- 5
- Issue
- 12
- Pages
- 2652-2660
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1705999641
- Cited by
- 507
- References
- 51
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Raetz, C. R. H., Ulevitch, R. I., Wright, S. D., Sibley, C. H., Ding, A., & Nathan, C. F. (1991). Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction 1. The FASEB Journal. https://doi.org/10.1096/fasebj.5.12.1916089
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