LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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Macrophage uptake and lysosomal degradation of modified pro-atherogenic lipoproteins lowers the extracellular concentration of these lipoproteins.
“uptake and ensuing lysosomal hydrolytic degradation of these pro-atherogenic lipoproteins by macrophages lowers the concentration of the pro-inflammatory lipoproteins in the extracellular fluid21.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [21]
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- Authors
- Brown, M. S., & Goldstein, J. L.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1983-06
- Volume
- 52
- Issue
- 1
- Pages
- 223-261
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2162458714
- Cited by
- 2,300
- References
- 0
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 19 · 2023: 15 · 2022: 25 · 2021: 20 · 2020: 28 · 2019: 22 · 2018: 30 · 2017: 25 · 2016: 24 · 2015: 37 · 2014: 37 · 2013: 29 · 2012: 38
- FWCI
- 95.97
- Type
- journal article
- Language
- ps
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- lipoprotein metabolism, macrophages, cholesterol deposition, atherosclerosis, foam cells, Hippo signaling pathway, cell growth regulation, organ size control
- MeSH terms
- Animals, Apolipoproteins, Apolipoproteins E, Arteriosclerosis, Cholesterol, Cholesterol Esters, Humans, Kinetics, Lipoproteins, Lipoproteins, LDL, Macrophages, Receptors, Cell Surface, Receptors, LDL, Cell Adhesion Molecules, Receptors, Scavenger, Mice
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