The DOI matches its Crossref record.
Role of phospholipases in generating lipid second messengers in signal transduction 1
Abstract
Many lipids or lipid‐derived products generated by phospholipases acting on phospholipids in membranes are implicated as mediators and second messengers in signal transduction. Our current understanding of the primary sequence relationships within the class of extracellular phospholipase A 2 's and among the numerous forms of the mammalian phosphatidylinositol‐specific phospholipase C's is reviewed. New results suggesting roles for these phospholipases as well as other phospholipases such as phospholipase C and D acting on phosphatidlycholine in generating arachidonic acid for eicosanoid biosynthesis, inositol phosphates for Ca 2+ mobilization, and diglyceride for protein kinase C activation through receptor‐mediated processes, are discussed. In addition, the possible role of phospholipases acting on sphingolipids such as sphinglomyelinase in generating lipid mediators is considered.—Dennis, E. A.; Rhee, S. G.; Billah, M. M.; Hannun, Y. A. Role of phospholipases in generating lipid second messengers in signal transduction. FASEB J. 5: 2068–2077; 1991.
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Cited by
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00128-6 · Cited by 555
Kozak, K. R., Crews, B. C., Morrow, J. D., Wang, L.-H., Ma, Y. H., Weinander, R., Jakobsson, P.-J., & Marnett, L. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206788200 · Cited by 368
Brain lipidomics: From functional landscape to clinical significance
Yoon, J. H., Seo, Y., Jo, Y. S., Lee, S., Cho, E., Cazenave-Gassiot, A., Shin, Y.-S., Moon, M. H., An, H. J., Wenk, M. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9317 · Cited by 324
The enterocyte microvillus is a vesicle-generating organelle
McConnell, R. E., Higginbotham, J. N., Shifrin, D. A., Tabb, D. L., Coffey, R. J., & Tyska, M. J. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902147 · Cited by 260
Ca 2+ -induced contraction of cat esophageal circular smooth muscle cells
Cao, W., Chen, Q., Sohn, U. D., Kim, N., Kirber, M. T., Harnett, K. M., Behar, J., & Biancani, P. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.4.c980 · Cited by 28
Metadata
- Authors
- Dennis, E. A., Rhee, S. G., Billah, M. M., & Hannun, Y. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1991-04
- Volume
- 5
- Issue
- 7
- Pages
- 2068-2077
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1603439931
- Cited by
- 542
- References
- 0
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dennis, E. A., Rhee, S. G., Billah, M. M., & Hannun, Y. A. (1991). Role of phospholipases in generating lipid second messengers in signal transduction 1. The FASEB Journal. https://doi.org/10.1096/fasebj.5.7.1901288
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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