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Trans-splicing of pre-mRNA in plants, animals, and protists.
Abstract
Messenger RNA maturation in eukaryotes typically involves the removal of introns from long precursor molecules. An unusual form of RNA splicing in which separate precursor transcripts contribute sequences to the mature mRNA through intermolecular reactions has now been documented in a number of diverse organisms. In this review, the phenomenon of pre-mRNA trans-splicing has been divided into two categories. The "spliced leader" type, found in protozoans such as trypanosomes and lower invertebrates such as nematodes, results in the addition of a short, capped 5' noncoding sequence to the mRNA. The "discontinuous group II intron" form of trans-splicing, found in plant/algal chloroplasts and plant mitochondria, involves the joining of independently transcribed coding sequences, presumably through interactions between "intronic" RNA pieces. Both categories of trans-splicing are mechanistically similar to conventional nuclear pre-mRNA cis-splicing; potential evolutionary relationships are discussed.
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Cited by
On the Possibility of Constructive Neutral Evolution
Stoltzfus, A. (1999) · Journal of Molecular Evolution · doi:10.1007/pl00006540 · Cited by 533
Lambowitz, A. M., & Zimmerly, S. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091600 · Cited by 448
Complex Spliceosomal Organization Ancestral to Extant Eukaryotes
Collins, L., & Penny, D. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi091 · Cited by 240
Metadata
- Authors
- Bonen, L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1993-01
- Volume
- 7
- Issue
- 1
- Pages
- 40-46
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1673194361
- Cited by
- 173
- References
- 0
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
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