The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Mobile Group II Introns
Abstract
▪ Abstract Mobile group II introns, found in bacterial and organellar genomes, are both catalytic RNAs and retrotransposable elements. They use an extraordinary mobility mechanism in which the excised intron RNA reverse splices directly into a DNA target site and is then reverse transcribed by the intron-encoded protein. After DNA insertion, the introns remove themselves by protein-assisted, autocatalytic RNA splicing, thereby minimizing host damage. Here we discuss the experimental basis for our current understanding of group II intron mobility mechanisms, beginning with genetic observations in yeast mitochondria, and culminating with a detailed understanding of molecular mechanisms shared by organellar and bacterial group II introns. We also discuss recently discovered links between group II intron mobility and DNA replication, new insights into group II intron evolution arising from bacterial genome sequencing, and the evolutionary relationship between group II introns and both eukaryotic spliceosomal introns and non-LTR-retrotransposons. Finally, we describe the development of mobile group II introns into gene-targeting vectors, “targetrons,” which have programmable target specificity.
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Self-citationThe age and evolution of non-LTR retrotransposable elements
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STRUCTURE AND ACTIVITIES OF GROUP II INTRONS
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Bentley, S. D., Aanensen, D. M., Mavroidi, A., Saunders, D., Rabbinowitsch, E., Collins, M., Donohoe, K., Harris, D., Murphy, L., Quail, M. A., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020031 · Cited by 759
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Selfish genetic elements, genetic conflict, and evolutionary innovation
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Metadata
- Authors
- Lambowitz, A. M., & Zimmerly, S.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2004-12-01
- Volume
- 38
- Issue
- 1
- Pages
- 1-35
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2100581167
- Cited by
- 448
- References
- 102
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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