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Fibrogenic cytokines and connective tissue production
Abstract
The pathogenesis of fibrotic disorders is similar regardless of the tissues involved. Inflammatory leukocytes infiltrate the site triggered by chemotactic and activating mediators. This is followed by the elaboration of cytokines that directly and indirectly induce the proliferation of fibroblasts and endothelial cells and the deposition of extracellular matrix (ECM). In the absence of inhibitory signals, the continued production of these mediators sustains the connective tissue accumulation, which results in permanent alteration in tissue structure and function.— Kovacs, E. J., DiPietro, L. A. Fibrogenic cytokines and connective tissue production. FASEB J. 8: 854‐861; 1994.
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Cited by
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BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Inflammation and wound healing: the role of the macrophage
Koh, T. J., & DiPietro, L. A. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001943 · Cited by 1,667
Self-citationInflammatory Cytokines in the BAL of Patients With ARDS
Meduri, G. U., Kohler, G., Headley, S., Tolley, E., Stentz, F., & Postlethwaite, A. (1995) · Chest · doi:10.1378/chest.108.5.1303 · Cited by 695
Chakir, J., Shannon, J., Molet, S., Fukakusa, M., Elias, J., Laviolette, M., Boulet, L.-P., & Hamid, Q. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1557 · Cited by 639
Fibroblast Differentiation in Wound Healing and Fibrosis
Darby, I. A., & Hewitson, T. D. (2007) · International Review of Cytology · doi:10.1016/s0074-7696(07)57004-x · Cited by 600
Metadata
- Authors
- Kovacs, E. J., & Dipietro, L. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1994-08
- Volume
- 8
- Issue
- 11
- Pages
- 854-861
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1795980252
- Cited by
- 422
- References
- 0
- FWCI
- 28.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kovacs, E. J., & Dipietro, L. A. (1994). Fibrogenic cytokines and connective tissue production. The FASEB Journal. https://doi.org/10.1096/fasebj.8.11.7520879
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
