Inflammatory Cytokines in the BAL of Patients With ARDS
Abstract
Background Inflammatory cytokines (ICs) are important modulators of injury and repair. ICs have been found to be elevated in the BAL of patients with both early and late ARDS. We tested the hypothesis that recurrent injury to the alveolocapillary barrier and amplification of intra-alveolar fibroproliferation observed in nonresolving ARDS is related to a persistent inflammatory response. For this purpose, we obtained serial measurements of BAL IC and correlated these levels with lung injury score (LIS), BAL indexes of endothelial permeability (albumin, total protein [TP]), and outcome.Methods We prospectively studied 27 consecutive patients with severe medical ARDS. Using enzyme-linked immunosorbent assay methods, levels of tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL) 1 beta, 2, 4, 6, and 8 were measured at frequent intervals in both plasma and BAL. In 22 patients, bilateral BAL was obtained on day 1 of ARDS and at weekly intervals when possible. Right and left BALs were analyzed separately for IC levels, total cell count and differential, albumin, TP, and quantitative bacterial cultures.Results On day 1 of ARDS, the 10 nonsurvivors had significantly higher (p = 0.0002) BAL TNF-alpha, IL-1 beta, IL-6, and IL-8 levels, which remained persistently elevated over time, indicating a continuous injury process. In contrast, the 12 survivors had a lesser elevation and a rapid reduction over time. Initial BAL IL-2 and IL-4 levels were significantly higher in patients with sepsis (p = 0.006); both increased over time in survivors and nonsurvivors. BAL levels of TNF-alpha, IL-1 beta, IL-6, and IL-8 correlated with BAL albumin and TP concentrations but not with LIS or ratio of arterial oxygen tension to inspired oxygen concentration. BAL: plasma ratios were elevated for all measured cytokines, suggesting a pulmonary origin. On day 1 of ARDS, nonsurvivors had significantly higher (p = 0.04) BAL: plasma ratios for TNF-alpha, IL-1 beta, IL-6, and IL-8. Over time, BAL:plasma ratios for TNF-alpha, IL-1 beta and IL-6 remained elevated in nonsurvivors and decreased in survivors.Conclusions Our findings indicate that an unfavorable outcome in ARDS is associated with an initial, exaggerated, pulmonary inflammatory response that persists unabated over time. Plasma IC levels parallel changes in BAL IC levels. The BAL:plasma ratio results suggest, but do not prove, a pulmonary origin for IC production. BAL TNF-alpha, IL-1 beta, and IL-8 levels correlated with BAL indices of endothelial permeability. In survivors, reduction in BAL IC levels over time was associated with a decline in BAL albumin and TP levels, suggesting effective repair of the endothelial surface. These findings support a causal relationship between degree and duration of lung inflammation and progression of fibroproliferation in ARDS.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cells of innate immunity increase in number and activation in alveolar injury, causing the alveolar concentration of molecules related to the host stress response to increase.
“The cells of innate immunity (macrophages and neutrophils) increase in number and activation, which causes the alveolar concentration of molecules related to the host stress response to increase.”
From The microbiome and critical illness (2016) · cites this paper as [117]
Cites
Biometry: The Principles and Practice of Statistics in Biological Research
Sokal, R. R., & Rohlf, F. J. (1969) · Cited by 20,963 · see citing works
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
Biometry. The Principles and Practice of Statistics in Biological Research
Fienberg, S. E., Sokal, R. R., Rohlf, F. J., Rohlf, F. J., & Sokal, R. R. (1970) · Biometrics · doi:10.2307/2529087 · Cited by 9,363 · see citing works
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · see citing works
An Expanded Definition of the Adult Respiratory Distress Syndrome
Murray, J. F., Matthay, M. A., Luce, J. M., & Flick, M. R. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.3.720 · Cited by 2,641 · see citing works
Bone, R. C. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-457 · Cited by 1,357 · see citing works
Prognosis in Acute Organ-System Failure
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Annals of Surgery · doi:10.1097/00000658-198512000-00004 · Cited by 1,220 · see citing works
Waage, A., Brandtzaeg, P., Halstensen, A. I., Kierulf, P., & Espevik, T. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.333 · Cited by 1,175 · see citing works
Waage, A., Halstensen, A. I., & Espevik, T. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91728-4 · Cited by 1,085 · see citing works
Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome
Casey, L. C., Balk, R. A., & Bone, R. C. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-8-199310150-00001 · Cited by 1,053 · see citing works
High-Dose Corticosteroids in Patients with the Adult Respiratory Distress Syndrome
Bernard, G. R., Luce, J. M., Sprung, C. L., Rinaldo, J. E., Tate, R. M., Sibbald, W. J., Kariman, K., Higgins, S. B., Bradley, R., Metz, C. A., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712173172504 · Cited by 927 · see citing works
Serum Cytokine Levels in Human Septic Shock
Pinsky, M. R., Vincent, J., Deviere, J. M., Alegre, M., Kahn, R. J., & Dupont, É. (1993) · CHEST Journal · doi:10.1378/chest.103.2.565 · Cited by 880 · see citing works
Increased plasma levels of interleukin-6 in sepsis [see comments]
Hack, C. E., de Groot, E. R., Felt-Bersma, R. J. F., Nuijens, J. H., van Schijndel, R. J. M. S., Eerenberg, A. J. M., THIJS, L. G., & Aarden, L. A. (1989) · Blood · doi:10.1182/blood.v74.5.1704.1704 · Cited by 811 · see citing works
Cytokine Serum Level During Severe Sepsis in Human IL-6 as a Marker of Severity
DAMA, P., Ledoux, D., Nys, M., Vrindts, Y., Groote, D. D., Franchimont, P., & Lamy, M. (1992) · Annals of Surgery · doi:10.1097/00000658-199204000-00009 · Cited by 808 · see citing works
Persistent Elevation of Inflammatory Cytokines Predicts a Poor Outcome in ARDS
Meduri, G. U., Headley, S., Kohler, G., Stentz, F. B., Tolley, E. A., Umberger, R. A., & Leeper, K. V. (1995) · CHEST Journal · doi:10.1378/chest.107.4.1062 · Cited by 788 · see citing works
Self-citationTumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura
Girardin, E. P., Grau, G. E., Dayer, J., Roux-Lombard, P., the J5 Study Group*, & Lambert, P.-H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190703 · Cited by 737 · see citing works
Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups
Donnelly, S. C., Haslett, C., Strieter, R. M., Kunkel, S. L., Walz, A., Robertson, C. R., Carter, D. C., Pollok, A., & Grant, I. S. (1993) · The Lancet · doi:10.1016/0140-6736(93)90416-e · Cited by 674 · see citing works
Roumen, R. M. H., Hendriks, T., van der Ven‐Jongekrijg, J., Nieuwenhuijzen, G. A. P., Sauerwein, R. W., van der Meer, J. W. M., & Goris, R. J. A. (1993) · Annals of Surgery · doi:10.1097/00000658-199312000-00011 · Cited by 617 · see citing works
Kumar, R. K. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.5.1234 · Cited by 559 · see citing works
Bachofen, M., & Weibel, E. R. (1977) · American Review of Respiratory Disease · doi:10.1164/arrd.1977.116.4.589 · Cited by 555 · see citing works
Calandra, T., Baumgartner, J. D., Grau, G. E., Wu, M.-M., Lambert, P., Schellekens, J. F. P., Verhoef, J., Glauser, M. P., & Swiss-Dutch J5 Immunoglobulin Study Group (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/161.5.982 · Cited by 546 · see citing works
Suter, P. M., Suter, S., Girardin, E. P., Roux‐Lombard, P., Grau, G. E., & Dayer, J. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.5.1016 · Cited by 516 · see citing works
Postlethwaite, A. E., Holness, M. A., Katai, H., & Raghow, R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116015 · Cited by 504 · see citing works
Self-citationTumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans
Damas, P., REUTER, A. M., Gysen, P., Demonty, J., Lamy, M., & Franchimont, P. (1989) · Critical Care Medicine · doi:10.1097/00003246-198910000-00001 · Cited by 486 · see citing works
Miller, E. J., Cohen, A. B., Nagao, S., Griffith, D. E., Maunder, R. J., Martin, T. R., Weiner-Kronish, J. P., Sticherling, M., Christophers, E., & Matthay, M. A. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.2.427 · Cited by 472 · see citing works
Kelley, J. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.3.765 · Cited by 460 · see citing works
(1987) · Journal of Critical Care · doi:10.1016/0883-9441(87)90015-3 · Cited by 451 · see citing works
Calandra, T., Gérain, J., Heumann, D., Baumgartner, J.-D., & Glauser, M. P. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90069-a · Cited by 443 · see citing works
Fisher, C. J., Opal, S. M., Dhainaut, J.-F., Stephens, S., Zimmerman, J. L., Nightingale, P., Harris, S., Schein, R. M. H., Panacek, E. A., Vincent, J., et al. (1993) · Critical Care Medicine · doi:10.1097/00003246-199303000-00006 · Cited by 425 · see citing works
Fibrogenic cytokines and connective tissue production
Kovacs, E. J., & DiPietro, L. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.11.7520879 · Cited by 425 · see citing works
Meduri, G. U., Mauldin, G. L., Wunderink, R. G., Leeper, K. V., Jones, C. B., Tolley, E. A., & Mayhall, G. (1994) · CHEST Journal · doi:10.1378/chest.106.1.221 · Cited by 338 · see citing works
Self-citationMarks, J. D., Marks, C. B., Ljuce, J. M., Montgomery, A. B., Turner, J., Metz, C. A., & Murray, J. F. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.94 · Cited by 329 · see citing works
Fibroproliferative Phase of ARDS
Meduri, G. U., Belenchia, J. M., Estes, R. J., Wunderink, R. G., Eltorky, M., & Leeper, K. V. (1991) · CHEST Journal · doi:10.1378/chest.100.4.943 · Cited by 305 · see citing works
Self-citationThe Standardization of Bronchoscopic Techniques for Ventilator-Associated Pneumonia
Meduri, G. U., & Chastre, J. E. (1992) · CHEST Journal · doi:10.1378/chest.102.5_supplement_1.557s · Cited by 295 · see citing works
Self-citationCorticosteroid Rescue Treatment of Progressive Fibroproliferation in Late ARDS
Meduri, G. U., Chinn, A. J., Leeper, K. V., Wunderink, R. G., Tolley, E. A., Winer-Muram, H. T., Khare, V. K., & Eltorky, M. (1994) · CHEST Journal · doi:10.1378/chest.105.5.1516 · Cited by 276 · see citing works
Self-citationWeiland, J. E., Wb, D., Holter, J. F., Mohammed, J. R., Dorinsky, P. M., & Gadek, J. E. (1986) · PubMed · doi:10.1164/arrd.1986.133.2.218 · Cited by 273 · see citing works
Cytokine Networks in the Regulation of Inflammation and Fibrosis in the Lung
Elias, J. A., Freundlich, B., Kern, J. A., & Rosenbloom, J. (1990) · CHEST Journal · doi:10.1378/chest.97.6.1439 · Cited by 262 · see citing works
Pathologic features and mechanisms of hypoxemia in adult respiratory distress syndrome.
Lamy, M., Fallat, R. J., Koeniger, E., Dietrich, H. P., Ratliff, J. L., Eberhart, R. C., Tucker, H. J., & Hill, J. D. (1976) · PubMed · doi:10.1164/arrd.1976.114.2.267 · Cited by 258 · see citing works
Xing, Z., Jordana, M., Kirpalani, H., Driscoll, K. E., Schall, T. J., & Gauldie, J. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.10.2.8110470 · Cited by 257 · see citing works
Adult respiratory distress syndrome. Prognosis after onset.
Fowler, A. A., Hamman, R. F., Zerbe, G. O., Benson, K. N., & Hyers, T. M. (1985) · PubMed · doi:10.1164/arrd.1985.132.3.472 · Cited by 220 · see citing works
Marano, M. A., Fong, Y., Moldawer, L. L., Wei, H., Calvano, S. E., Tracey, K. J., Barie, P. S., Manogue, K., Cerami, A., & Shires, G. T. (1990) · PubMed · Cited by 219 · see citing works
Chollet‐Martin, S., Montravers, P., Gibert, C., Elbim, C., Desmonts, J.-M., Fagon, J.-Y., & Gougerot‐Pocidalo, M. (1993) · Infection and Immunity · doi:10.1128/iai.61.11.4553-4559.1993 · Cited by 218 · see citing works
MARTY, C., Misset, B., Tamion, F., Fitting, C., Carlet, J. M., & Cavaillon, J. (1994) · Critical Care Medicine · doi:10.1097/00003246-199404000-00025 · Cited by 212 · see citing works
Cerami, A. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90035-m · Cited by 199 · see citing works
Millar, A., Singer, M., Meager, A., Foley, N. M., Johnson, N. M., & Rook, G. A. W. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90772-1 · Cited by 198 · see citing works
Hyers, T. M., Tricomi, S. M., Dettenmeier, P. A., & Fowler, A. A. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.2.268 · Cited by 192 · see citing works
Alveolitis and Collapse in the Pathogenesis of Pulmonary Fibrosis
Burkhardt, A. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/140.2.513 · Cited by 179 · see citing works
Jacobs, R. F., Tabor, D. R., Burks, A. W., & Campbell, G. D. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/140.6.1686 · Cited by 158 · see citing works
Production of monoclonal antibodies against interleukin-1α and -1β
Grassi, J. J., Frobert, Y., Pradelles, P., Chercuitte, F., Chatellard-Gruaz, D., Dayer, J., & Poubelle, P. E. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90223-8 · Cited by 144 · see citing works
Plasma and BAL Cytokine Response to Corticosteroid Rescue Treatment in Late ARDS
Meduri, G. U., Headley, S., Tolley, E. A., Shelby, M., Stentz, F. B., & Postlethwaite, A. E. (1995) · CHEST Journal · doi:10.1378/chest.108.5.1315 · Cited by 141 · see citing works
Self-citationJorens, P. G., Damme, J. V., Backer, W. D., Bossaert, L., Jongh, R. F. D., Herman, A. G., & Rampart, M. (1992) · Cytokine · doi:10.1016/1043-4666(92)90025-m · Cited by 139 · see citing works
Postlethwaite, A. E., & Seyer, J. M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115247 · Cited by 139 · see citing works
Self-citationLoss of Compartmentalization of Alveolar Tumor Necrosis Factor After Lung Injury
Tutor, J. D., Mason, C. M., Dobard, E., Beckerman, R. C., Summer, W. R., & Nelson, S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.5.8173748 · Cited by 135 · see citing works
Adult respiratory distress syndrome: Prognosis after onset
(1986) · Journal of Critical Care · doi:10.1016/s0883-9441(86)80118-6 · Cited by 117 · see citing works
Pathogenesis of fibrosis in acute lung injury
Bitterman, P. B. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90606-c · Cited by 113 · see citing works
Postlethwaite, A. E., & Seyer, J. M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1749 · Cited by 112 · see citing works
Self-citationMoscovitz, H. C., Shofer, F. S., Mignott, H., Behrman, A. J., & Kilpatrick, L. E. (1994) · Critical Care Medicine · doi:10.1097/00003246-199407000-00009 · Cited by 99 · see citing works
Regulation of lung cell proliferation by polypeptide growth factors
King, R., Jones, M., & Minoo, P. (1989) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1989.257.2.l23 · Cited by 87 · see citing works
Meade, P. C., Shoemaker, W. C., Donnelly, T. J., Abraham, E. H., Jagels, M. A., Cryer, H. G., Hugli, T. E., BISHOP, M. H., & Wo, C. C. J. (1994) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199405000-00009 · Cited by 86 · see citing works
Siler, T. M., Swierkosz, J. E., Hyers, T. M., Fowler, A. A., & Webster, R. O. (1989) · Experimental Lung Research · doi:10.3109/01902148909069633 · Cited by 84 · see citing works
Pulmonary Endothelial Permeability in Patients With Severe Lung Injury
Sinclair, D. G., Braude, S., HASLAM, P. L., & Evans, T. W. (1994) · CHEST Journal · doi:10.1378/chest.106.2.535 · Cited by 75 · see citing works
Bitterman, P. B., & Henke, C. A. (1991) · CHEST Journal · doi:10.1378/chest.99.3_supplement.81s · Cited by 59 · see citing works
Nhieu, J. T. V., Misset, B., Lebargy, F., Carlet, J. M., & Bernaudin, J. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.6_pt_1.1585 · Cited by 58 · see citing works
Heffner, J. E., & Zamora, C. A. (1990) · CHEST Journal · doi:10.1378/chest.97.2.447 · Cited by 57 · see citing works
Kawamura, M., Yamasawa, F., Ishizaka, A., Kato, R., Kikuchi, K., Kobayashi, K., Aoki, T., Sakamaki, F., Hasegawa, N., & Kawashiro, T. (1994) · Thorax · doi:10.1136/thx.49.2.144 · Cited by 33 · see citing works
Harris, T. R., Bernard, G. R., Brigham, K. L., Higgins, S. B., Rinaldo, J. E., Borovetz, H. S., Sibbald, W. J., Kariman, K., & Sprung, C. L. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.272 · Cited by 31 · see citing works
TUMOUR NECROSIS FACTOR AND ADULT RESPIRATORY DISTRESS SYNDROME
Roberts, D. J., Davies, J. M., Evans, C. C., Bell, M., Mostafa, S. M., & Lamche, H. R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91058-1 · Cited by 25 · see citing works
Chollet‐Martin, S., Montravers, P., Gibert, C., Elbim, C., Desmonts, J.-M., Fagon, J.-Y., & Gougerot‐Pocidalo, M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39818.x · Cited by 13 · see citing works
Raponi, G., Antonelli, M. M., Gaeta, A., Bufi, M., Blasi, R. A. D., Conti, G., D’Errico, R. R., Mancini, C., Filadoro, F., & GASPARETTO, A. (1992) · Journal of Critical Care · doi:10.1016/0883-9441(92)90015-y · Cited by 13 · see citing works
Levels of Interleukin-8 in Patients with Adult Respiratory Distress Syndrome
Torre, D., Zeroli, C., Gioia, M. C. D., Fiori, G. P., Minoja, G., Maraggia, D., & Chiaranda, M. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.2.505 · Cited by 13 · see citing works
The challenge of adult respiratory distress syndrome during interleukin-2 immunotherapy.
Farrell, M. M. (1992) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 72 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Acute respiratory distress syndrome
Matthay, M. A., Zemans, R. L., Zimmerman, G. A., Arabi, Y. M., Beitler, J. R., Mercat, A., Herridge, M. S., Randolph, A. G., & Calfee, C. S. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0069-0 · Cited by 2,420 · see citing works
Ranieri, V. M., Suter, P. M., Tortorella, C., Tullio, R. D., Dayer, J.-M., BRIENZA, A., Bruno, F., & Slutsky, A. S. (1999) · JAMA · doi:10.1001/jama.282.1.54 · Cited by 1,882 · see citing works
McGonagle, D., Sharif, K., O'Regan, A., & Bridgewood, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102537 · Cited by 1,654 · see citing works
Tremblay, L., Valenza, F., Ribeiro, S. P., Li, J., & Slutsky, A. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119259 · Cited by 1,326 · see citing works
COVID-19 cytokine storm: the interplay between inflammation and coagulation
José, R. J. P., & Manuel, A. R. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30216-2 · Cited by 1,241 · see citing works
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
Bhatia, M., & Moochhala, S. (2003) · The Journal of Pathology · doi:10.1002/path.1491 · Cited by 1,087 · see citing works
Sepsis: A New Hypothesis for Pathogenesis of the Disease Process
Bone, R. C., Grodzin, C. J., & BALK, R. A. (1997) · CHEST Journal · doi:10.1378/chest.112.1.235 · Cited by 1,019 · see citing works
Effect of Prolonged Methylprednisolone Therapy in Unresolving Acute Respiratory Distress Syndrome
Meduri, G. U., Headley, A. S., Golden, E. B., Carson, S. J., Umberger, R. A., Kelso, T. M., & Tolley, E. A. (1998) · JAMA · doi:10.1001/jama.280.2.159 · Cited by 998 · see citing works
Self-citationAcute Lung Injury: A Clinical and Molecular Review
Butt, Y. M., Kurdowska, A., & Allen, T. C. (2016) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2015-0519-ra · Cited by 898 · see citing works
Multiple System Organ Failure: Is Mechanical Ventilation a Contributing Factor?
Slutsky, A. S., & Tremblay, L. N. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9709092 · Cited by 834 · see citing works
Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment
Johnson, E., & Matthay, M. A. (2010) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2009.0775 · Cited by 785 · see citing works
Dickson, R. P., Singer, B. H., Newstead, M. W., Falkowski, N. R., Erb-Downward, J. R., Standiford, T. J., & Huffnagle, G. B. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.113 · Cited by 724 · see citing works
Soluble Triggering Receptor Expressed on Myeloid Cells and the Diagnosis of Pneumonia
Gibot, S., Cravoisy, A., Lévy, B., Béné, M. C., Faure, G. C., & Bollaert, P. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031544 · Cited by 640 · see citing works
Role of TNFα in pulmonary pathophysiology
Mukhopadhyay, S., Hoidal, J. R., & Mukherjee, T. K. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-125 · Cited by 580 · see citing works
Cytokine Balance in the Lungs of Patients with Acute Respiratory Distress Syndrome
PARK, W. Y., GOODMAN, R. B., STEINBERG, K. P., RUZINSKI, J. T., RADELLA, F., PARK, D. R., PUGIN, J., SKERRETT, S. J., HUDSON, L. D., & MARTIN, T. R. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2104013 · Cited by 547 · see citing works
Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?
Biffl, W., Moore, E. E., Moore, F., & Peterson, V. M. (1996) · Annals of Surgery · doi:10.1097/00000658-199611000-00009 · Cited by 558 · see citing works
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Lung microbiome: new insights into the pathogenesis of respiratory diseases
Li, R., Li, J., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01722-y · Cited by 466 · see citing works
Targeting the NLRP3 Inflammasome in Severe COVID-19
Freeman, T. L., & Swartz, T. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01518 · Cited by 406 · see citing works
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, J. A., Keane, M. P., Burdick, M. D., Londhe, V. A., Xue, Y., Li, K., Phillips, R. J., & Strieter, R. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15849 · Cited by 447 · see citing works
Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome
Matute‐Bello, G., Liles, W. C., Radella, F., Steinberg, K. P., RUZINSKI, J. T., Jonas, M., CHI, E. Y., Hudson, L. D., & MARTIN, T. R. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.6.96-12081 · Cited by 394 · see citing works
ACUTE RESPIRATORY DISTRESS SYNDROME
Conner, B. D., & Bernard, G. R. (2000) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70167-2 · Cited by 382 · see citing works
Cytokine mediated tissue fibrosis
Borthwick, L. A., Wynn, T. A., & Fisher, A. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.014 · Cited by 375 · see citing works
Mowery, N. T., Terzian, W. T. H., & Nelson, A. C. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100777 · Cited by 323 · see citing works
Both Erk and p38 Kinases Are Necessary for Cytokine Gene Transcription
Carter, A. B., Monick, M. M., & Hunninghake, G. W. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.4.3420 · Cited by 305 · see citing works
Schwartz, M. D., Moore, E. E., Moore, F. A., Shenkar, R., Moine, P., Haenel, J. B., & Abraham, E. H. (1996) · Critical Care Medicine · doi:10.1097/00003246-199608000-00004 · Cited by 287 · see citing works
Hack, C. E., Aarden, L. A., & THUS, L. G. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60597-0 · Cited by 284 · see citing works
Fibroproliferation Occurs Early in the Acute Respiratory Distress Syndrome and Impacts on Outcome
Marshall, R. P., Bellingan, G. J., Webb, S., Puddicombe, A., Goldsack, N., McAnulty, R. J., & Laurent, G. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.5.2001061 · Cited by 281 · see citing works
Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy
Klein, C. L., Hoke, T. S., Fang, W., Altmann, C. J., Douglas, I. S., & Faubel, S. G. (2008) · Kidney International · doi:10.1038/ki.2008.314 · Cited by 279 · see citing works
Pivotal Advance: Th‐1 cytokines inhibit, and Th‐2 cytokines promote fibrocyte differentiation
Shao, D., Suresh, R., Vakil, V., Gomer, R., & Pilling, D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107782 · Cited by 288 · see citing works
COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?
Colafrancesco, S., Alessandri, C., Conti, F., & Priori, R. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102573 · Cited by 272 · see citing works
Meduri, G. U., Bridges, L., Shih, M., Marik, P. E., Siemieniuk, R. A. C., & Koçak, M. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-4095-4 · Cited by 264 · see citing works
Self-citationNitric Oxide and Nitrotyrosine in the Lungs of Patients with Acute Respiratory Distress Syndrome
Sittipunt, C., Steinberg, K. P., RUZINSKI, J. T., Myles, C., Zhu, S., Goodman, R. B., Hudson, L. D., Matalon, S., & MARTIN, T. R. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2004187 · Cited by 261 · see citing works
Activation and Regulation of Systemic Inflammation in ARDS
Meduri, G. U., Annane, D., Chrousos, G. P., Marik, P. E., & Sinclair, S. E. (2009) · CHEST Journal · doi:10.1378/chest.08-2408 · Cited by 260 · see citing works
Self-citationInfections and the Inflammatory Response in Acute Respiratory Distress Syndrome
Headley, A. S., Meduri, G. U., & Tolley, E. A. (1997) · CHEST Journal · doi:10.1378/chest.111.5.1306 · Cited by 259 · see citing works
Self-citationBiomarkers in Acute Lung Injury: Insights into the Pathogenesis of Acute Lung Injury
Cross, L. J. M., & Matthay, M. A. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.12.005 · Cited by 257 · see citing works
Transcriptional mechanisms of acute lung injury
Fan, J., Ye, R. D., & Malik, A. B. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.5.l1037 · Cited by 252 · see citing works
Sheeran, P., Jafri, H. S., Carubelli, C. M., SAAVEDRA, J., JOHNSON, C., Krisher, K., Sánchez, P. J., & Ramilo, O. (1999) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199902000-00007 · Cited by 251 · see citing works
Endothelial Damage in Acute Respiratory Distress Syndrome
Vassiliou, A. G., Kotanidou, Α., Dimopoulou, I., & Orfanos, S. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228793 · Cited by 239 · see citing works
Nuclear Factor–κB and Its Role in Sepsis‐Associated Organ Failure
Abraham, E. H. (2003) · The Journal of Infectious Diseases · doi:10.1086/374750 · Cited by 235 · see citing works
Annane, D., Pastores, S. M., Arlt, W., Balk, R. A., Beishuizen, A., Briegel, J., Carcillo, J., Christ-Crain, M., Cooper, M. S., Marik, P. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4914-x · Cited by 220 · see citing works
Self-citationSeki, H., Fukunaga, K., Arita, M., Arai, H., Nakanishi, H., Taguchi, R., Miyasho, T., Takamiya, R., Asano, K., Ishizaka, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901809 · Cited by 221 · see citing works
Natural history of COVID-19 and current knowledge on treatment therapeutic options
dos Santos, W. G. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110493 · Cited by 222 · see citing works
Acute respiratory distress syndrome
Confalonieri, M., Salton, F., & Fabiano, F. (2017) · European Respiratory Review · doi:10.1183/16000617.0116-2016 · Cited by 220 · see citing works
Bordón, J., Aliberti, S., Fernandez-Botrán, R., Uriarte, S. M., Rane, M. J., Duvvuri, P. D., Peyrani, P., Morlacchi, L. C., Blasi, F., & Ramírez, J. A. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.06.006 · Cited by 214 · see citing works
Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB
Zhu, T., Wang, D., Zhang, W., Liao, X., Guan, X., Bo, H., Sun, J.-Y., Huang, N., He, J., Zhang, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056407 · Cited by 212 · see citing works
Stüber, F., Wrigge, H., Schroeder, S., Wetegrove, S., Zinserling, J., Hoeft, A., & Putensen, C. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1321-7 · Cited by 211 · see citing works
Ghrelin Attenuates Sepsis-induced Acute Lung Injury and Mortality in Rats
Wu, R., Dong, W., Zhou, M., Zhang, F., Marini, C. P., Ravikumar, T. S., & Wang, P. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-511oc · Cited by 204 · see citing works
Ito, J. T., Lourenço, J. D., Righetti, R. F., Tibério, I. D. F. L. C., Prado, C. M., & Lopes, F. D. T. Q. D. S. (2019) · Cells · doi:10.3390/cells8040342 · Cited by 200 · see citing works
Mechanisms and mediators of lung injury after acute kidney injury
Faubel, S. G., & Edelstein, C. L. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.158 · Cited by 196 · see citing works
AGGARWAL, A., Baker, C. S., Evans, T., & Haslam, P. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.15e14.x · Cited by 194 · see citing works
Reutershan, J., & Ley, K. F. (2004) · Critical Care · doi:10.1186/cc2881 · Cited by 193 · see citing works
The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study
Esper, A. M., Moss, M. M., & Martin, G. S. (2009) · Critical Care · doi:10.1186/cc7717 · Cited by 188 · see citing works
Pacht, E. R., DeMichele, S. J., Nelson, J. L., Hart, J., Wennberg, A. K., & Gadek, J. E. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000049952.96496.3e · Cited by 191 · see citing works
Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice
Zhang, B., Liu, Z.-Y., Li, Y., Luo, Y., Liu, M.-L., Dong, H., Wang, Y., Liu, Y., Zhao, P., Jin, F., et al. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.09.020 · Cited by 186 · see citing works
Meduri, G. U., Tolley, E. A., Chinn, A. J., Stentz, F. B., & Postlethwaite, A. E. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9801107 · Cited by 185 · see citing works
Self-citationCoagulation Blockade Prevents Sepsis-induced Respiratory and Renal Failure in Baboons
Welty‐Wolf, K. E., Carraway, M. S., Miller, D. L., Ortel, T. L., Ezban, M., Ghio, A. J., Idell, S., & Piantadosi, C. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2105027 · Cited by 171 · see citing works
Ashley, S. L., Sjoding, M. W., Popova, A. P., Cui, T. X., Hoostal, M. J., Schmidt, T. M., Branton, W. R., Dieterle, M. G., Falkowski, N. R., Baker, J. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aau9959 · Cited by 170 · see citing works
Meduri, G. U., Muthiah, M. P., Carratù, P., Eltorky, M., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000091126 · Cited by 167 · see citing works
Self-citationRahman, M. M., Bibi, S., Rahaman, M. S., Rahman, F., Islam, F., Khan, M. S., Hasan, M. M., Parvez, A., Hossain, M. A., Maeesa, S. K., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113041 · Cited by 168 · see citing works
RetractedCytokine expression in severe pneumonia: A bronchoalveolar lavage study
Montón, C., Torres, A., El-Ebiary, M., Filella, X., Xaubet, A., & de la Bellacasa, J. P. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00008 · Cited by 160 · see citing works
ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME IN SEPSIS AND SEPTIC SHOCK
Fein, A. M., & Calalang-Colucci, M. G. (2000) · Critical Care Clinics · doi:10.1016/s0749-0704(05)70111-1 · Cited by 158 · see citing works
The Role of Exogenous Surfactant in the Treatment of Acute Lung Injury
Lewis, J. F., & Veldhuizen, R. A. W. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142434 · Cited by 160 · see citing works
LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1
Qiu, N., Xu, X., & He, Y. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-1084-3 · Cited by 159 · see citing works
Imanaka, H., Shimaoka, M., Matsuura∥, N., Nishimura, M., Ohta, N., & Kiyono, H. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200102000-00029 · Cited by 159 · see citing works
Rezende-Neto, J., Moore, E. E., de Andrade, M. V. M., Teixeira, M. M., Lisboa, F., Arantes, R. M. E., de Souza, D. G., & Cunha-Melo, J. (2002) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-200212000-00015 · Cited by 158 · see citing works
Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema
Kubo, K., Hanaoka, M., Hayano, T., Miyahara, T., Hachiya, T., Hayasaka, M., Koizumi, T., Fujimoto, K., Kobayashi, T., & Honda, T. (1998) · Respiration Physiology · doi:10.1016/s0034-5687(98)00006-1 · Cited by 158 · see citing works
Bauer, T. T. (2000) · Thorax · doi:10.1136/thorax.55.1.46 · Cited by 157 · see citing works
Cytokines IL-1 β, IL-6, and TNF- α Enhance <i>In Vitro</i> Growth of Bacteria
MEDURI, G. U., KANANGAT, S., STEFAN, J., TOLLEY, E., & SCHABERG, D. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.3.9807080 · Cited by 155 · see citing works
Self-citationKuronuma, K., Mitsuzawa, H., Takeda, K., Nishitani, C., Chan, E. D., Kuroki, Y., Nakamura, M., & Voelker, D. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040832 · Cited by 154 · see citing works
Martin, T. R. (1999) · CHEST Journal · doi:10.1378/chest.116.suppl_1.2s · Cited by 154 · see citing works
Tremblay, L. N., Miatto, D., Hamid, Q. A., Govindarajan, A., & Slutsky, A. S. (2002) · Critical Care Medicine · doi:10.1097/00003246-200208000-00003 · Cited by 153 · see citing works
Lin, S., Wu, H., Wang, C., Xiao, Z., & Xu, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01545 · Cited by 152 · see citing works
A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome
Blondonnet, R., Constantin, J., Sapin, V., & Jabaudon, M. (2016) · Disease Markers · doi:10.1155/2016/3501373 · Cited by 153 · see citing works
Ding, Z., Zhong, R., Yang, Y., Xia, T., Wang, W., Wang, Y., Xing, N., Luo, Y., Li, S., Shang, L., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104759 · Cited by 150 · see citing works
Ware, L. B. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000155788.39101.7e · Cited by 149 · see citing works
Inflammatory serum markers in patients with multiple trauma
Giannoudis, P. V., Hildebrand, F., & Pape, H. (2004) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.86b3.15035 · Cited by 147 · see citing works
Rahimi, V. B., Rakhshandeh, H., Raucci, F., Buono, B., Shirazinia, R., Samzadeh‐Kermani, A., Μaione, F., Mascolo, N., & Askari, V. R. (2019) · Molecules · doi:10.3390/molecules24010139 · Cited by 145 · see citing works
Waltuch, T., Gill, P., Zinns, L. E., Whitney, R., Tokarski, J., Tsung, J. W., & Sanders, J. E. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.05.058 · Cited by 145 · see citing works
Downregulation of ENaC activity and expression by TNF-α in alveolar epithelial cells
Dagenais, A., Fréchette, R., Yamagata, Y., Yamagata, T., Carmel, J., Clermont, M.-E., Brochiero, E., Massé, C., & Berthiaume, Y. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00326.2002 · Cited by 144 · see citing works
Imai, Y., Kawano, T., Iwamoto, S., Nakagawa, S., Takata, M., & Miyasaka, K. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.2.510 · Cited by 143 · see citing works
Corticosteroids in Acute Respiratory Failure
Jantz, M. A., & Sahn, S. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.4.9901075 · Cited by 143 · see citing works
Plasma and BAL Cytokine Response to Corticosteroid Rescue Treatment in Late ARDS
Meduri, G. U., Headley, S., Tolley, E. A., Shelby, M., Stentz, F. B., & Postlethwaite, A. E. (1995) · CHEST Journal · doi:10.1378/chest.108.5.1315 · Cited by 141 · see citing works
Self-citationModulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis
Lee, S., Jang, A., Kim, Y.-E., Cha, J.-Y., Kim, T.-H., Jung, S., Park, S.-K., Lee, Y.-K., Won, J.-H., Kim, Y., et al. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-16 · Cited by 139 · see citing works
The acute respiratory distress syndrome: fibrosis in the fast lane
Marshall, R. P., Bellingan, G. J., & Laurent, G. J. (1998) · Thorax · doi:10.1136/thx.53.10.815 · Cited by 138 · see citing works
Gallagher, D. C., Parikh, S. M., Balonov, K., Miller, A. C., Gautam, S., Talmor, D. S., & Sukhatme, V. P. (2008) · Shock · doi:10.1097/shk.0b013e31815dd92f · Cited by 133 · see citing works
Kambas, K., Markiewski, M. M., Pneumatikos, I. A., Rafail, S. S., Theodorou, V., Konstantonis, D., Kourtzelis, I., Doumas, M. N., Magotti, P., DeAngelis, R. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7368 · Cited by 127 · see citing works
Glucocorticoids and Inflammation Revisited: The State of the Art
Franchimont, D. P., Kino, T., Galon, J., Meduri, G. U., & Chrousos, G. P. (2002) · NeuroImmunoModulation · doi:10.1159/000069969 · Cited by 131 · see citing works
Self-citationRole of microparticles in sepsis
Reid, V. L., & Webster, N. R. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes321 · Cited by 130 · see citing works
Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice
Ahuja, N. H., Andrés-Hernando, A., Altmann, C. J., Bhargava, R., Bacalja, J., Webb, R. G., He, Z., Edelstein, C. L., & Faubel, S. G. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00025.2012 · Cited by 130 · see citing works
Meduri, G. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09122650 · Cited by 129 · see citing works
Self-citationEarly Alterations in Neutrophil Activation Are Associated with Outcome in Acute Lung Injury
Yang, K., Arcaroli, J. J., & Abraham, E. H. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-664oc · Cited by 127 · see citing works
Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome
Raghavendran, K., Pryhuber, G., Chess, P. R., Davidson, B. A., Knight, P. R., & Notter, R. H. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708785132942 · Cited by 124 · see citing works
Dose-Response to Inhaled Aerosolized Prostacyclin for Hypoxemia Due to ARDS
van Heerden, P. V., Barden, A. E., Michalopoulos, N., Bulsara, M. K., & Roberts, B. (2000) · CHEST Journal · doi:10.1378/chest.117.3.819 · Cited by 123 · see citing works
Duong, M., Ouellet, N., Simard, M., Bergeron, Y., Olivier, M., & Bergeron, M. G. (1998) · The Journal of Infectious Diseases · doi:10.1086/314425 · Cited by 120 · see citing works
Die Bedeutung der Zytokine in der posttraumatischen Entzündungsreaktion
Hildebrand, F., Pape, H., & Krettek, C. (2005) · Der Unfallchirurg · doi:10.1007/s00113-005-1005-1 · Cited by 119 · see citing works
Annane, D., Pastores, S. M., Arlt, W., BALK, R. A., Beishuizen, A., Briegel, J., Carcillo, J. A., Christ‐Crain, M., Cooper, M. S., Marik, P. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002724 · Cited by 118 · see citing works
Self-citationChu, X., Ci, X., He, J., Jiang, L., Wei, M., Cao, Q., Guan, M., Xie, X., Deng, X., & He, J. (2012) · Molecules · doi:10.3390/molecules17033586 · Cited by 116 · see citing works
Baudouin, S. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg083 · Cited by 116 · see citing works
Diagnostic workup for ARDS patients
Papazian, L., Calfee, C. S., Chiumello, D., Luyt, C. E., Meyer, N. J., Sekiguchi, H., Matthay, M. A., & Meduri, G. U. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4324-5 · Cited by 111 · see citing works
Self-citation
- Authors
- Meduri, G. U., Kohler, G., Headley, S., Tolley, E., Stentz, F., & Postlethwaite, A.
- Affiliations
- University of Tennessee Health Science Center (US)
- Memphis VA Medical Center (US)
- Corresponding author
- Meduri, G. Umberto
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 108
- Issue
- 5
- Pages
- 1303-1314
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2153354364
- Cited by
- 695
- References
- 72
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 14 · 2023: 23 · 2022: 44 · 2021: 47 · 2020: 51 · 2019: 19 · 2018: 12 · 2017: 18 · 2016: 18 · 2015: 23 · 2014: 16 · 2013: 21 · 2012: 20
- FWCI
- 19.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (5M01RR-00211, M01RR000211)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- acute respiratory distress syndrome, inflammatory cytokines, bronchoalveolar lavage, TNF-α, interleukin-6, interleukin-8, IL-1β, interleukin-2, IL-4, endothelial permeability, sepsis, lung injury score
- MeSH terms
- Adult, Bronchoalveolar Lavage Fluid, Cell Membrane Permeability, Endothelium, Female, Humans, Inflammation, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Proteins, Respiratory Distress Syndrome, Cytokines, Hospital Mortality, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review