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Cited by 277

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Integrins as dynamic regulators of vascular function

Luscinskas, Francis W., Lawler, Jack·1994·The FASEB Journal

Abstract

The vascular endothelium lines the entire cardiovascular system and serves as a nonthrombogenic and selectively permeable boundary between the bloodstream and extravascular space. Endothelial cells are polar cells that are continuously subjected to fluid‐generated forces on their luminal surface whereas their abluminal surface resides on basement membranes/extracellular matrix. The integrin family of cell‐surface heterodimeric glycoproteins is located along both of these surfaces and participates in maintaining the normal endothelium and in the dynamic changes associated with the pathophysiology of the endothelium. Endothelial cell β 1 and β 3 integrins function together with other families of adhesion molecules during vasculogenesis, angiogenesis, inflammation, and wound healing. Leukocyte β 1 and β 2 integrins, in conjunction with members of the Ig and selectin gene families expressed on endothelium, mediate leukocyte recruitment to sites of inflammation. The structural and functional properties of integrins make them uniquely suited to mediate these essential and complex processes in the vasculature.— Luscinskas, F. W., Lawler, J. Integrins as dynamic regulators of vascular function. FASEB J. 8: 929‐938; 1994.

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Metadata

Authors
Luscinskas, F. W., & Lawler, J.
Venue
The FASEB Journal
Publisher
Wiley
Published
1994-09
Volume
8
Issue
12
Pages
929-938
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
OpenAlex
W1886264513
Cited by
277
References
77
FWCI
7.25
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Integrins as dynamic regulators of vascular function. https://app.cochat.ai/papers/10.1096/fasebj.8.12.7522194
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Luscinskas, F. W., & Lawler, J. (1994). Integrins as dynamic regulators of vascular function. The FASEB Journal. https://doi.org/10.1096/fasebj.8.12.7522194

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.