Angiongenesis: a new theory for endometriosis
Abstract
Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis.
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Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.
“Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [76]
Cites
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486 · see citing works
Requirement of Vascular Integrin α <sub>v</sub> β <sub>3</sub> for Angiogenesis
Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020 · see citing works
Rw, N., Hertig, A. T., & Rock, J. A. (1950) · Fertility and Sterility · doi:10.1016/s0015-0282(16)30062-0 · Cited by 2,854 · see citing works
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334 · see citing works
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262 · see citing works
Revised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803 · see citing works
Brooks, P. C., Strömblad, S., Sanders, L. C., Schalscha, T. V., Aimes, R. T., Stetler‐Stevenson, W. G., Quigley, J. P., & Cheresh, D. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81235-0 · Cited by 1,552 · see citing works
Definition of Two Angiogenic Pathways by Distinct α v Integrins
Friedlander, M., Brooks, P. C., Shaffer, R. W., Kincaid, C. M., Varner, J. A., & Cheresh, D. A. (1995) · Science · doi:10.1126/science.270.5241.1500 · Cited by 1,310 · see citing works
(1984) · PubMed · Cited by 997 · see citing works
Studies on the surgical induction of endometriosis in the rat.
Vernon, M. W., & Wilson, E. A. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48988-0 · Cited by 482 · see citing works
Oosterlynck, D. J., Cornillie, F. J., Waer, M., Vandeputte, M., & Koninckx, P. R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54414-8 · Cited by 441 · see citing works
The Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise
Cramer, D. W. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03370140102032 · Cited by 367 · see citing works
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.
Parangi, S., OʼReilly, M., Christofori, G., Holmgren, L., Grosfeld, J. A., Folkman, J., & Hanahan, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.2002 · Cited by 343 · see citing works
The Human Hematopoietic Progenitor Cell Antigen (CD 3 4) in Vascular Neoplasia
Traweek, S. T., Kandalaft, P. L., Mehta, P., & Battifora, H. A. (1991) · American Journal of Clinical Pathology · doi:10.1093/ajcp/96.1.25 · Cited by 296 · see citing works
Proliferation kinetics of human endometrium during the normal menstrual cycle
Ferenczy, A. S., Bertrand, G., & Gelfand, M. M. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90302-8 · Cited by 291 · see citing works
Integrins as dynamic regulators of vascular function
Luscinskas, F. W., & Lawler, J. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.12.7522194 · Cited by 277 · see citing works
Angiogenesis in reproductive tissues
Findlay, J. K. (1986) · Journal of Endocrinology · doi:10.1677/joe.0.1110357 · Cited by 254 · see citing works
Angiogenic activity of peritoneal fluid from women with endometriosis
Oosterlynck, D. J., Meuleman, C., Sobis, H., Vandeputte, M., & Koninckx, P. R. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55859-2 · Cited by 182 · see citing works
Cell proliferation is increased in the endometrium of women with endometriosis
Wingfield, M. B., Macpherson, A., Healy, D. L., & Rogers, P. A. W. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57733-4 · Cited by 155 · see citing works
Peritoneal fluid: its relevance to the development of endometriosis
Ramey, J. W., & Archer, D. F. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56027-0 · Cited by 151 · see citing works
Sepp, N. T., Li, L.-J., Lee, K. H., Brown, E. J., Caughman, S. W., Lawley, T. J., & Swerlick, R. A. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12394617 · Cited by 136 · see citing works
Family trait analysis: A case-control study of 43 women with endometriosis and their best friends
Lamb, K., Hoffmann, R. G., & Nichols, T. R. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90608-3 · Cited by 98 · see citing works
Hii, L. L., & Rogers, P. A. W. (1998) · Human Reproduction · doi:10.1093/humrep/13.4.1030 · Cited by 88 · see citing works
Endometrial endothelial cell proliferation during the menstrual cycle
Goodger(Macpherson), A. M., & Rogers, P. A. W. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138516 · Cited by 87 · see citing works
Endothelial cell migratory signal produced by human endometrium during the menstrual cycle
Rogers, P. A. W., Abberton, K. M., & Susil, B. J. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137793 · Cited by 86 · see citing works
Bergqvist, A., Ljungberg, O., & Skoog, L. K. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137960 · Cited by 82 · see citing works
Enenstein, J., & Kramer, R. H. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12395390 · Cited by 77 · see citing works
Isaacson, K., Galman, M., Coutifaris, C., & Lyttle, C. R. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53518-3 · Cited by 72 · see citing works
STUDIES ON THE VASCULAR PATTERN OF ECTOPIC ENDOMETRIUM WITH SPECIAL REFERENCE TO CYCLIC CHANGES
Nieminen, U. (1962) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016346209157175 · Cited by 41 · see citing works
Endothelial integrins and their role in maintaining the integrity of the vessel wall
Dejana, E., Raiteri, M., Resnati, M., & Lampugnani, M. G. (1993) · Kidney International · doi:10.1038/ki.1993.11 · Cited by 33 · see citing works
Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis
Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., & Kitao, M. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53721-2 · Cited by 31 · see citing works
Immunofluorescence shows localisation of prolactin to human amnion
Healy, D. L., Muller, H. K., & Burger, H. (1977) · Nature · doi:10.1038/265642a0 · Cited by 30 · see citing works
In vitro CA-125 secretion by endometrium from women with advanced endometriosis
McBean, J. H., & Brumsted, J. R. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55620-9 · Cited by 28 · see citing works
Endometriosis impairs glycogen synthesis in human endometrium.
Ishihara, S., Taketani, Y., & Mizuno, M. (1992) · PubMed · Cited by 8 · see citing works
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Endometriosis: epidemiology and aetiological factors
Viganò, P., Parazzini, F., Somigliana, E., & Vercellini, P. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.01.007 · Cited by 718 · see citing works
Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427 · see citing works
Oxidative stress and peritoneal endometriosis
Van Langendonckt, A., Casanas-Roux, F., & Donnez, J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02959-x · Cited by 391 · see citing works
Precursor lesions of ovarian epithelial malignancy
Feeley, K. M., & Wells, M. L. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01042.x · Cited by 351 · see citing works
Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?
Matarese, G., De Placido, G., Nikas, Y., & Alviggi, C. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00051-0 · Cited by 315 · see citing works
Vinatier, D., Orazi, G., Cosson, M., & Dufour, P. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00405-x · Cited by 299 · see citing works
Reactive Oxygen Species Controls Endometriosis Progression
Ngô, C., Chéreau, C., Nicco, C., Weill, B., Chapron, C., & Batteux, F. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080804 · Cited by 292 · see citing works
Vascular endothelial growth factor and endometriotic angiogenesis
McLaren, J. (2000) · Human Reproduction Update · doi:10.1093/humupd/6.1.45 · Cited by 269 · see citing works
Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis
Donnez, J., Binda, M. M., Donnez, O., & Dolmans, M.-M. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.1075 · Cited by 251 · see citing works
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241 · see citing works
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2006) · Human Reproduction · doi:10.1093/humrep/dei368 · Cited by 236 · see citing works
Somigliana, E., Viganò, P., Rossi, G., Carinelli, S. G., Vignali, M., & Panina‐Bordignon, P. (1999) · Human Reproduction · doi:10.1093/humrep/14.12.2944 · Cited by 218 · see citing works
The search for genes contributing to endometriosis risk
Montgomery, G. W., Nyholt, D. R., Zhao, Z. Z., Treloar, S. A., Painter, J. N., Missmer, S. A., Kennedy, S. H., & Zondervan, K. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn016 · Cited by 211 · see citing works
Macrophage expression in endometrium of women with and without endometriosis
Berbic, M., Schulke, L., Markham, R., Tokushige, N., Russell, P. J., & Fraser, I. S. (2008) · Human Reproduction · doi:10.1093/humrep/den393 · Cited by 204 · see citing works
Treloar, S. A., Wicks, J., Nyholt, D. R., Montgomery, G. W., Bahlo, M., Smith, V. E., Dawson, G., Mackay, I., Weeks, D. E., Bennett, S. T., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/432960 · Cited by 195 · see citing works
Бурлев, В. А., Volkov, N. I., Pavlovitch, S. V., Lets, N., Larsson, A. O., & Olovsson, M. (2006) · Reproduction · doi:10.1530/rep.1.01110 · Cited by 192 · see citing works
Endometriosis: Current Therapies and New Pharmacological Developments
Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Barbara, G., & Crosignani, P. G. (2009) · Drugs · doi:10.2165/00003495-200969060-00002 · Cited by 182 · see citing works
Smooth muscles are frequent components of endometriotic lesions
Anaf, V. (2000) · Human Reproduction · doi:10.1093/humrep/15.4.767 · Cited by 183 · see citing works
Laschke, M. W., & Menger, M. D. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm006 · Cited by 177 · see citing works
Heritability and molecular genetic studies of endometriosis
Bischoff, F. Z. (2000) · Human Reproduction Update · doi:10.1093/humupd/6.1.37 · Cited by 168 · see citing works
Berbic, M., Hey‐Cunningham, A. J., Ng, C. H. M., Tokushige, N., Ganewatta, S. P., Markham, R., Russell, P. J., & Fraser, I. S. (2010) · Human Reproduction · doi:10.1093/humrep/deq020 · Cited by 158 · see citing works
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.078 · Cited by 151 · see citing works
Anti-angiogenic treatment strategies for the therapy of endometriosis
Laschke, M. W., & Menger, M. D. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms026 · Cited by 151 · see citing works
Iron overload in the peritoneal cavity of women with pelvic endometriosis
Van Langendonckt, A., Casanas-Roux, F., & Donnez, J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03346-0 · Cited by 137 · see citing works
Regulatory T cells and other leukocytes in the pathogenesis of endometriosis
Berbic, M., & Fraser, I. S. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2010.11.004 · Cited by 135 · see citing works
Endometriosis: current and future medical therapies
Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Daguati, R., & Crosignani, P. G. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.10.001 · Cited by 136 · see citing works
Xavier, P., Belo, L., Beires, J., Rebelo, I., Martinez-de-Oliveira, J., Lunet, N., & Barros, H. (2006) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-005-0080-4 · Cited by 130 · see citing works
Basic mechanisms of vascularization in endometriosis and their clinical implications
Laschke, M. W., & Menger, M. D. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy001 · Cited by 128 · see citing works
Gilabert–Estellés, J., Ramón, L., España, F., Gilabert, J., Vila, V., Regañón, E., Castelló, R., Chirivella, M., & Estellés, A. (2007) · Human Reproduction · doi:10.1093/humrep/dem149 · Cited by 126 · see citing works
Increased Leptin Levels in Serum and Peritoneal Fluid of Patients with Pelvic Endometriosis1
Matarese, G., Alviggi, C., Sanna, V., Howard, J. K., Lord, G. M., Carravetta, C., Fontana, S., Lechler, R. I., Bloom, S. R., & Placido, G. D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6703 · Cited by 126 · see citing works
The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1
Jerman, L. F., & Hey-Cunningham, A. J. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.124313 · Cited by 122 · see citing works
Fasciani, A. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.1.50 · Cited by 120 · see citing works
Matsuzaki, S., Canis, M. J., Vaurs‐Barrière, C., Pouly, J.-L., Boespflug‐Tanguy, O., Penault-Llorca, F. M., Dechelotte, P., Dastugue, B., Okamura, K., & Mage, G. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah097 · Cited by 117 · see citing works
Mitigation of endometriosis using regenerative cerium oxide nanoparticles
Chaudhury, K., Narendra Babu, K., Singh, A. K., Das, S., Kumar, A., & Seal, S. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.08.001 · Cited by 118 · see citing works
Mechsner, S., Schwarz, J., Thode, J., Loddenkemper, C., Salomon, D. S., & Ebert, A. D. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.087 · Cited by 114 · see citing works
Is endometriosis an endometrial disease?
Vinatier, D., Cosson, M., & Dufour, P. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00263-8 · Cited by 115 · see citing works
Okada, H. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.4.341 · Cited by 104 · see citing works
Zhang, H., Niu, Y., Feng, J., Guo, H., Ye, X., & Cui, H. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.01.028 · Cited by 101 · see citing works
Laschke, M. W., Elitzsch, A., Scheuer, C., Vollmar, B., & Menger, M. D. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.068 · Cited by 100 · see citing works
Laschke, M. W., Schwender, C., Scheuer, C., Vollmar, B., & Menger, M. D. (2008) · Human Reproduction · doi:10.1093/humrep/den245 · Cited by 98 · see citing works
Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model
Efstathiou, J. A., Sampson, D. A., Levine, Z., Rohan, R. M., Zurakowski, D., Folkman, J., D’Amato, R. J., & Rupnick, M. A. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.06.058 · Cited by 96 · see citing works
A baboon model for endometriosis: implications for fertility
Hastings, J. M., & Fazleabas, A. T. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-s1-s7 · Cited by 89 · see citing works
Goteri, G., Lucarini, G., Montik, N., Zizzi, A., Stramazzotti, D., Fabris, G., Tranquilli, A. L., & Ciavattini, A. (2009) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318182c2be · Cited by 88 · see citing works
Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib
Doğan, E., Saygılı, U., Posacı, C., Tuna, B., Uysal, S., Altunyurt, S., & Saatli, B. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.06.033 · Cited by 85 · see citing works
A Novel Noninvasive Model of Endometriosis for Monitoring the Efficacy of Antiangiogenic Therapy
Becker, C. M., Wright, R. D., Satchi‐Fainaro, R., Funakoshi, T., Folkman, J., Kung, A. L., & D’Amato, R. J. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051133 · Cited by 84 · see citing works
Matsuzaki, S., Canis, M. J., Darcha, C., Dallel, R., Okamura, K., & Mage, G. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.07.946 · Cited by 83 · see citing works
Kats, R., Collette, T., Metz, C. N., & Akoum, A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03189-8 · Cited by 83 · see citing works
Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis.
Nasiri, N., Moini, A., Eftekhari‐Yazdi, P., Karimian, L., Yazdi, R. S., & Arabipoor, A. (2017) · PubMed Central · doi:10.22074/cellj.2016.4724 · Cited by 81 · see citing works
Selective Progesterone Receptor Modulators (SPRMs)
Chwalisż, K., Garg, R. C., Brenner, R., Schubert, G., & Elger, W. A. G. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02798.x · Cited by 77 · see citing works
Bedaiwy, M. A., Falcone, T., Goldberg, J. M., Sharma, R. K., Nelson, D. R., & Agarwal, A. K. (2005) · Human Reproduction · doi:10.1093/humrep/dei376 · Cited by 75 · see citing works
Insights into assessing the genetics of endometriosis
Rahmioglu, N., Missmer, S. A., Montgomery, G. W., & Zondervan, K. T. (2012) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-012-0016-5 · Cited by 71 · see citing works
Intrauterine exposures and risk of endometriosis
Louis, G. M. B., Hediger, M. L., & Pena, J. B. (2007) · Human Reproduction · doi:10.1093/humrep/dem338 · Cited by 71 · see citing works
Laschke, M. W., Elitzsch, A., Scheuer, C., Holstein, J. H., Vollmar, B., & Menger, M. D. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706857 · Cited by 70 · see citing works
Katayama, H., Katayama, T., Uematsu, K., Hiratsuka, M., Kiyomura, M., Shimizu, Y., Sugita, A., & Ito, M. (2010) · Human Reproduction · doi:10.1093/humrep/deq241 · Cited by 68 · see citing works
Angiogenesis lymphangiogenesis and neurogenesis in endometriosis
Hey‐Cunningham, A. J. (2013) · Frontiers in Bioscience-Elite · doi:10.2741/e682 · Cited by 68 · see citing works
Antiangiogenic and vascular-disrupting agents in endometriosis: pitfalls and promises
Langendonckt, A. V., Donnez, J., Defrère, S., Dunselman, G. A. J., & Groothuis, P. G. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan019 · Cited by 66 · see citing works
Kats, R., Metz, C. N., & Akoum, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8260 · Cited by 64 · see citing works
Becker, C. M., Sampson, D. A., Short, S. M., Javaherian, K., Folkman, J., & D’Amato, R. J. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.1290 · Cited by 62 · see citing works
Differential expression of MMP-2, MMP-9 and PCNA in endometriosis and endometrial carcinoma
Weigel, M. T., Krämer, J., Schem, C., Wenners, A. S., Alkatout, İ., Jonat, W., Maass, N., & Mundhenke, C. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.09.040 · Cited by 62 · see citing works
Zou, J., Wang, N., Liu, M., Bai, Y., Wang, H., Liu, K., Zhang, H., Xiao, X., & Wang, K. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13552 · Cited by 62 · see citing works
Thyroid Hormones Crosstalk with Growth Factors: Old Facts and New Hypotheses
Candelotti, E., Vito, P. D., Ahmed, R. G., Luly, P., Davis, P. J., Pedersen, J. Z., Lin, H., & Incerpi, S. (2015) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152221501150710131534 · Cited by 61 · see citing works
Ria, R., Loverro, G., Vacca, A., Ribatti, D., Cormio, G., Roccaro, A. M., & Selvaggi, L. E. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00960.x · Cited by 61 · see citing works
Zheng, W., Li, N., Wang, J., Ulukus, E. C., Ulukuş, M., Arici, A. M., & Liang, S. X. (2005) · International Journal of Gynecological Pathology · doi:10.1097/01.rct.0000157091.37057.b4 · Cited by 59 · see citing works
Angiopoietin-1, angiopoietin-2 and Tie-2 expression in eutopic endometrium in advanced endometriosis
Hur, S. E. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal049 · Cited by 58 · see citing works
The Estrogen Early Response Gene FOS Is Altered in a Baboon Model of Endometriosis1
Hastings, J. M., Jackson, K. S., Mavrogianis, P. A., & Fazleabas, A. T. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.106.052852 · Cited by 55 · see citing works
Kang, S., Shizhen, L., Wang, N., Zhou, R., Wang, T., Wang, D.-J., Li, X.-F., Bui, J., & Li, Y. (2010) · Human Reproduction · doi:10.1093/humrep/deq128 · Cited by 54 · see citing works
Placido, G. D. (2001) · Human Reproduction · doi:10.1093/humrep/16.6.1251 · Cited by 53 · see citing works
Rai, P., Kota, V., Sundaram, C. S., Deendayal, M., & Shivaji, S. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900094 · Cited by 49 · see citing works
In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy
Laschke, M. W., Elitzsch, A., Vollmar, B., & Menger, M. D. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.05.010 · Cited by 49 · see citing works
Cyclic sciatica from extrapelvic endometriosis affecting the sciatic nerve
Floyd, J., Keeler, E. R., Euscher, E. D., & McCutcheon, I. E. (2010) · Journal of Neurosurgery Spine · doi:10.3171/2010.10.spine09162 · Cited by 46 · see citing works
Angiogenic activity and IL‐8 concentrations in peritoneal fluid and sera in endometriosis
Barcz, E., Różewska, E. S., Kamiński, P., Demkow, U. A., Bobrowska, K., & MARIANOWSKI, L. (2002) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(02)00308-9 · Cited by 46 · see citing works
Atorvastatin causes regression of endometriotic implants in a rat model
Yılmaz, B., Özat, M., Kılıç, S., Gungor, T., Aksoy, Y., Lordlar, N., Süt, N., & Aksakal, O. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.11.004 · Cited by 45 · see citing works
Role of the CXCL12–CXCR4 axis in the development of deep rectal endometriosis
Leconte, M., Chouzenoux, S., Nicco, C., Chéreau, C., Arkwright, S., Santulli, P., Weill, B. J., Chapron, C., Dousset, B. E., & Batteux, F. (2014) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2013.12.121 · Cited by 45 · see citing works
Matsuzaki, S., Canis, M. J., Murakami, T., Dechelotte, P., Bruhat, M. A., & Okamura, K. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02003-9 · Cited by 44 · see citing works
The gut microbiota: a double-edged sword in endometriosis
Talwar, C., Singh, V., & Kommagani, R. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac147 · Cited by 44 · see citing works
Laudański, P., Charkiewicz, R., Kuźmicki, M., Szamatowicz, J., Swiatecka, J., Mroczko, B., & Nikliński, J. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.10.007 · Cited by 42 · see citing works
In vitro and in vivo anti-angiogenic effects of hydroxyurea
Lopes, F. C. M., Ferreira, R., de Albuquerque, D. M., Silveira, A. A. A., Costa, R., Soares, R. A., Costa, F. F., & Conran, N. (2014) · Microvascular Research · doi:10.1016/j.mvr.2014.05.009 · Cited by 41 · see citing works
Gazvani, R., Smith, L., & Fowler, P. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02954-5 · Cited by 40 · see citing works
Serum Leptin Concentrations in Endometriosis
Viganò, P., Somigliana, E., Matrone, R., Dubini, A., Barron, C., Vignali, M., & Blasio, A. M. D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8286 · Cited by 39 · see citing works
Nothnick, W. B., Graham, A. R., Holbert, J., & Weiss, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100336 · Cited by 36 · see citing works
Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis
Бурлев, В. А., Larsson, A. O., & Olovsson, M. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.08.064 · Cited by 36 · see citing works
Proteomic analysis of protein expression in the eutopic endometrium of women with endometriosis
ten Have, S., Fraser, I. S., Markham, R., Lam, A. M., & Matsumoto, I. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200600743 · Cited by 36 · see citing works
Vascularisation in Deep Endometriosis: A Systematic Review with Narrative Outcomes
Powell, S. G., Sharma, P., Masterson, S., Wyatt, J. N. R., Arshad, I., Ahmed, S., Lash, G. E., Cross, M. J., & Hapangama, D. K. (2023) · Cells · doi:10.3390/cells12091318 · Cited by 34 · see citing works
Chen, Z., Dai, Y., Dong, Z., Li, M., Mu, X., Zhang, R., Wang, Z., Zhang, W., Lang, J., Leng, J., et al. (2012) · Integrative Biology · doi:10.1039/c2ib00172a · Cited by 34 · see citing works
Paracrine regulation of endometriotic tissue
Minici, F., Tiberi, F., Tropea, A., Miceli, F., Orlando, M., Gangale, M. F., Romani, F., Catino, S., Campo, S., Lanzone, A., et al. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701581721 · Cited by 33 · see citing works
Macrophage-derived netrin-1 is critical for neuroangiogenesis in endometriosis
Guo, X., Ding, S., Li, T., Wang, J., Yu, Q., Zhu, L., Xu, X., Zou, G., Peng, Y., & Zhang, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.130 · Cited by 33 · see citing works
Ovarian endometrioma vascularization in women with pelvic pain
Alcázar, J. L., & García-Manero, M. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.106 · Cited by 32 · see citing works
da Silva, C. M., Belo, A. V., Andrade, S. P., Campos, P. P., Ferreira, M. C. F., Filho, A. L. D. S., & Carneiro, M. M. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.08.005 · Cited by 31 · see citing works
Ceyhan, S. T., Öngürü, Ö., Başer, İ., & Günhan, Ö. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.07.1332 · Cited by 31 · see citing works
Comparison of efficacy of bromocriptine and cabergoline to GnRH agonist in a rat endometriosis model
Ercan, C. M., Kayaalp, O., Cengiz, M., Keskin, U., Yumuşak, N., Aydoğan, Ü., İde, T., & Ergün, A. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3524-x · Cited by 30 · see citing works
Edwards, D. S., Jones, P. A., Haramis, H., Battle, M. R., Lear, R., Barnett, D. J., Edwards, C., Crawford, H., Black, A., & Godden, V. (2008) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2007.11.010 · Cited by 31 · see citing works
AL‐JEFOUT, M., PALMER, J., & FRASER, I. S. (2007) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2007.00727.x · Cited by 29 · see citing works
Increased expression of endoglin in the eutopic endometrium of women with endometriosis
Kim, S. H., Choi, Y. M., Chae, H. D., Kim, K. R., Kim, C. H., & Kang, B. M. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02733-9 · Cited by 29 · see citing works
Endometriosis: current concepts and therapy
VALLE, R. F. (2002) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(02)00132-7 · Cited by 28 · see citing works
García-Manero, M., Alcázar, J. L., & Toledo, G. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.117 · Cited by 28 · see citing works
Lin, W., Chen, S., Li, M., Wang, B., Qu, X., & Zhang, Y. (2010) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2009.01123.x · Cited by 27 · see citing works
Erdem, Ö., Erdem, M., Erdem, A., Memis, L., & Akyol, G. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.00942.x · Cited by 24 · see citing works
Zhang, N., Ashikuzzaman, M., & Rivaz, H. J. (2020) · BioMedical Engineering OnLine · doi:10.1186/s12938-020-00778-z · Cited by 23 · see citing works
Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis
Barbosa, C. P., Teles, J. S., Lerner, T. G., Peluso, C., Mafra, F., Vilariño, F. L., Christofolini, D. M., & Bianco, B. A. V. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.01.125 · Cited by 22 · see citing works
Xavier, P. A. F., Beires, J., Barros, H., & Martinez‐de‐Oliveira, J. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.01.114 · Cited by 23 · see citing works
- Authors
- Healy, D.
- Affiliations
- Monash Medical Centre (AU)
- Corresponding author
- Healy, D.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 4
- Issue
- 5
- Pages
- 736-740
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2146205715
- Cited by
- 173
- References
- 34
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 9
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, endometrial angiogenesis, angiogenesis, endothelial cell proliferation, integrin αvβ3, adhesion molecules, peritoneal implantation, endometrial proliferation, anti-angiogenic therapy
- MeSH terms
- Cell Division, Endometriosis, Endometrium, Endothelium, Vascular, Female, Gene Expression Regulation, Humans, Models, Cardiovascular, Neoplasms, Neovascularization, Pathologic, Receptors, Vitronectin
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