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Structural and functional relationships of heterotrimeric G‐proteins
Abstract
Heterotrimeric GTP‐binding proteins (G‐proteins) are a critical component of signal transduction pathways that carry information received at the cell surface to the appropriate cellular effector system, ultimately achieving a specific cellular response. Heterotrimeric G‐proteins consist of an a‐subunit, which contains the guanine nucleotide binding site and intrinsic GTPase activity, and an inseparable βγ‐subunit complex. G‐proteins act to define the specificity by which a receptor regulates a particular intracellular signaling system, as well as to regulate the duration of the signal. A great deal of structural and functional insight into how G‐protein‐mediated signal transduction occurs has recently been achieved. This review will discuss the structural features of G‐proteins, as well as detail the mechanism by which G‐proteins interact with receptors and effectors.—Rens‐Domiano, S., Hamm, H. E. Structure and functional relationships of heterotrimeric G‐proteins. FASEBJ. 9, 1059‐1066 (1995)
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Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Metadata
- Authors
- Rens‐Domiano, S., & Hamm, H. E.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-08
- Volume
- 9
- Issue
- 11
- Pages
- 1059-1066
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1908186060
- Cited by
- 159
- References
- 0
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rens‐Domiano, S., & Hamm, H. E. (1995). Structural and functional relationships of heterotrimeric G‐proteins. The FASEB Journal. https://doi.org/10.1096/fasebj.9.11.7649405
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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