Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Abstract
The importance of β-adrenergic signaling in the heart has been well documented, but it is only more recently that we have begun to understand the importance of this signaling pathway in skeletal muscle. There is considerable evidence regarding the stimulation of the β-adrenergic system with β-adrenoceptor agonists (β-agonists). Although traditionally used for treating bronchospasm, it became apparent that some β-agonists could increase skeletal muscle mass and decrease body fat. These so-called “repartitioning effects” proved desirable for the livestock industry trying to improve feed efficiency and meat quality. Studying β-agonist effects on skeletal muscle has identified potential therapeutic applications for muscle wasting conditions such as sarcopenia, cancer cachexia, denervation, and neuromuscular diseases, aiming to attenuate (or potentially reverse) the muscle wasting and associated muscle weakness, and to enhance muscle growth and repair after injury. Some undesirable cardiovascular side effects of β-agonists have so far limited their therapeutic potential. This review describes the physiological significance of β-adrenergic signaling in skeletal muscle and examines the effects of β-agonists on skeletal muscle structure and function. In addition, we examine the proposed beneficial effects of β-agonist administration on skeletal muscle along with some of the less desirable cardiovascular effects. Understanding β-adrenergic signaling in skeletal muscle is important for identifying new therapeutic targets and identifying novel approaches to attenuate the muscle wasting concomitant with many diseases.
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Some repartitioning treatments such as β-adrenergic agonists act on skeletal muscle and adipose tissue at the same time.
“However, some repartitioning treatments such as β-adrenergic agonists act on skeletal muscle and adipose tissue at the same time.”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [183]
β-adrenergic agonists stimulate skeletal muscle hypertrophy and adipose lipolysis by acting on adrenergic receptors expressed by both tissues.
“A key example is β-adrenergic agonists, which stimulate skeletal muscle hypertrophy and adipose lipolysis by acting on adrenergic receptors expressed by both tissues [170, 183].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [183]
The rise in catecholamines during resistance training should stimulate white adipose tissue lipolysis and activate brown adipose tissue heat production, increasing energy expenditure.
“However, the rise in catecholamines during resistance training [188] should stimulate white adipose tissue lipolysis [183] and activate brown adipose tissue heat production [189], which will increase energy expenditure.”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [183]
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Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
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Muscle wasting in disease: molecular mechanisms and promising therapies
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Mirzoev, T. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217940 · Cited by 65 · see citing works
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“However, the rise in catecholamines during resistance training [188] should stimulate white adipose tissue lipolysis [183] and activate brown adipose tissue heat production [189], which will increase energy expenditure.”
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Campos, J. C., Baehr, L. M., Ferreira, N. D., Bozi, L. H. M., Andres, A. M., Ribeiro, M. A. C., Gottlieb, R. A., Bodine, S. C., & Ferreira, J. C. B. (2020) · The FASEB Journal · doi:10.1096/fj.201902305r · Cited by 10 · see citing works
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- Authors
- Lynch, G. S., & Ryall, J. G.
- Affiliations
- The University of Melbourne (AU)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2008-04
- Volume
- 88
- Issue
- 2
- Pages
- 729-767
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2034769638
- Cited by
- 410
- References
- 492
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 28 · 2023: 24 · 2022: 22 · 2021: 24 · 2020: 20 · 2019: 34 · 2018: 26 · 2017: 19 · 2016: 18 · 2015: 26 · 2014: 29 · 2013: 23 · 2012: 18
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Pharmacological Effects and Assays
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- beta-adrenergic signaling, skeletal muscle, beta-adrenergic agonists, muscle atrophy, sarcopenia, cancer cachexia, denervation, neuromuscular disorders, muscle growth, feed efficiency, cardiovascular side effects
- MeSH terms
- Adrenergic beta-Agonists, Animals, Humans, Receptors, Adrenergic, beta, Sympathetic Nervous System, Signal Transduction, Muscle, Skeletal, Wasting Syndrome, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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