The DOI matches its Crossref record.
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
Abstract
Regional fat distribution is an important determinant of insulin resistance in obesity. In the current study, the relationship between skeletal muscle insulin sensitivity, mid‐thigh muscle composition, and the metabolic profile of muscle was investigated. Muscle composition was assessed by computed tomography of the mid‐thigh, and by activities of marker enzymes of aerobic‐oxidative and glycolytic pathways and muscle fiber typing using biopsies of the vastus lateralis muscle. Muscle with reduced Hounsfield attenuation on computed tomography scans was increased in proportion to obesity, and was strongly related to insulin resistance, reduced muscle oxidative capacity, and increased anaerobic and glycolytic capacities by muscle. These findings suggest that as part of its expression of insulin resistance, skeletal muscle of obese individuals is also poorly equipped for substrate oxidation and manifests increased storage of fat.—Simoneau, J.‐A., Colberg, S. R., Thaete, F. L., Kelley, D. E. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 9, 273–278 (1995)
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“Impaired flexibility also correlates with intramyocellular accumulation of lipids (107), and 24-h RQ can predict subsequent weight gain (110, 113).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [107]
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Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
“(312) found that measurements of muscle fat and visceral obesity were independent predictors of insulin resistance.”
BackgroundResultMitsiopoulos, N., Baumgartner, R. N., Heymsfield, S. B., Lyons, W., Gallagher, D., & Ross, R. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.115 · Cited by 1,522
“A recent observation is that CT-derived muscle attenuation values are strong correlates of insulin resistance in obese subjects (24).”
BackgroundAttenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
“Lower skeletal muscle attenuation values on CT have also been associated with diminished muscle function as defined by reduced oxidative enzyme capacity (25), lower maximal aerobic capacity (11), and insulin resistance (11).”
BackgroundSelf-citationGoodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194
“with prior studies demonstrating that skeletal muscle from insulin-resistant and obese subjects is characterized by lower oxidative capacity (15, 17) and lower fasting rates of fatty acid oxidation (17, 48, 49).”
Metadata
- Authors
- Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E.
- Affiliations
- University of Pittsburgh (US)
- Veterans Health Administration (US)
- Corresponding author
- Kelley, David E.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 9
- Issue
- 2
- Pages
- 273-278
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1592900851
- Cited by
- 362
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 15 · 2016: 12 · 2015: 14 · 2014: 8 · 2013: 12 · 2012: 16
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30dk046204-15)
- National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK-46204)
- National Center for Research Resources (M01RR000056, 5 MO1 RR 00056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- skeletal muscle insulin sensitivity, insulin resistance, obesity, muscle composition, muscle fiber typing, glycolytic enzymes, oxidative enzymes, muscle fat content, regional fat distribution, vastus lateralis, aerobic metabolism, anaerobic metabolism, women
- MeSH terms
- Adenosine Triphosphatases, Adipose Tissue, Adult, Aerobiosis, Blood Glucose, Citrate (si)-Synthase, Creatine Kinase, Electron Transport Complex IV, Female, Glucose, Glyceraldehyde-3-Phosphate Dehydrogenases, Phosphorylases, Glycolysis, Hexokinase, Humans, Infusions, Intravenous, Insulin, Obesity, Phosphofructokinase-1, Thinness, Tomography, X-Ray Computed, 3-Hydroxyacyl CoA Dehydrogenases, Glucose Clamp Technique, Body Mass Index, Muscle, Skeletal, Muscle Fibers, Skeletal
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