The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Selenium deficiency increases the pathology of an influenza virus infection
Abstract
Selenium (Se) deficiency has previously been shown to induce myocarditis in mice infected with a benign strain of coxsackievirus. To determine if Se deficiency would also intensify an infection with influenza virus, Se‐deficient and Se‐adequate mice were infected with a mild strain of influenza, influenza A/Bangkok/1/79 (H3N2). Infected Se‐deficient mice developed much more severe interstitial pneumonitis than did Se‐adequate mice. This increase in pathology was associated with significant alterations in mRNA levels for cytokines and chemokines involved in pro‐inflammatory responses. These results demonstrate that adequate nutrition is required for protection against viral infection and suggest that nutritional deprivation may be one of many factors that increase the susceptibility of individuals to influenza infection.
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Cites
Chakraborti, S., & Chakraborti, T. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00014-x · Cited by 110 · cited 1×
“The nuclear factor, NF-κB, is thought to be up-regulated by an increase in oxidative stress (38).”
Background
Cited by
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330
Selenium biochemistry and its role for human health
Roman, M., Jitaru, P., & Barbante, C. (2014) · Metallomics · doi:10.1039/c3mt00185g · Cited by 823
Biogeochemistry of selenium and its impact on food chain quality and human health.
Hartikainen, H. (2005) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2005.02.009 · Cited by 651
Jones, D. P., & Sies, H. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6247 · Cited by 647
The argument for increasing selenium intake
Rayman, M. P. (2002) · Proceedings of the Nutrition Society · doi:10.1079/pns2002153 · Cited by 462
Metadata
- Authors
- Beck, M. A., Nelson, H. K., Shi, Q., Van Dael, P., Schiffrin, E. J., Blum, S., Barclay, D., & Levander, O. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2001-04-27
- Volume
- 15
- Issue
- 8
- Pages
- 1481-1483
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2159299677
- Cited by
- 290
- References
- 1
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beck, M. A., Nelson, H. K., Shi, Q., Van Dael, P., Schiffrin, E. J., Blum, S., Barclay, D., & Levander, O. A. (2001). Selenium deficiency increases the pathology of an influenza virus infection. The FASEB Journal. https://doi.org/10.1096/fj.00-0721fje
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
