The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
Abstract
Several studies have demonstrated unequivocally that certain nonsteroidal anti‐inflammatory drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, and flurbiprofen cause anti‐inflammatory and antiproliferative effects independent of cyclooxy‐genase activity and prostaglandin synthesis inhibition. These effects are mediated through inhibition of certain transcription factors such as NF‐κB and AP‐1. The respective NSAIDs might interfere directly with the transcription factors, but their effects are probably mediated predominantly through alterations of the activity of cellular kinases such as IKKß, Erk, p38 MAPK, or Cdks. These effects apparently are not shared by all NSAIDs, since indomethacin failed to inhibit NF‐κB and AP‐1 activation as well as Erk and Cdk activity. In contrast, indomethacin was able to activate PPARγ, which was not affected by sodium salicylate or aspirin. The differences in cyclooxygenase‐independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds.—Tegeder, I., Pfeilschifter, J., Geisslinger, G. Cyclooxygenase‐independent actions of cyclooxygenase inhibitors FASEB J. 15, 2057–2072 (2001)
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Ibuprofen: pharmacology, efficacy and safety
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NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
Eriksen, J. L., Sagi, S. A., Smith, T. E., Weggen, S., Das, P., McLendon, D. C., Ozols, V. V., Jessing, K. W., Zavitz, K. H., Koo, E. H., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18162 · Cited by 634
Diclofenac: an update on its mechanism of action and safety profile
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Metadata
- Authors
- Tegeder, I., Pfeilschifter, J., & Geisslinger, G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 15
- Issue
- 12
- Pages
- 2057-2072
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1998232267
- Cited by
- 747
- References
- 11
- FWCI
- 30.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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